Exostosin-like 2

BE0004629ProteinHumansEXTL2

Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. It is acted on by 3 drugs in DrugBank.

Gene name
EXTL2
UniProtKB entry
Q9UBQ6Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
330 residues · 37,465 Da
Also known as
2.4.1.223 · Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 · Alpha-GalNAcT EXTL2 · EXT-related protein 2 · EXTR2

Resolves to

Protein
UniProtQ9UBQ6UniProt nameEXTL2_HUMAN
Gene
HGNCHGNC:3516NCBI Gene2135GeneCardsEXTL2
Pharmacology
KEGGhsa:2135
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Exostosin-like 2, and which indications are they being tested in?

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