Neutral alpha-glucosidase AB

BE0004698ProteinHumansGANAB

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). It is acted on by 17 drugs in DrugBank.

Gene name
GANAB
UniProtKB entry
Q14697Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
944 residues · 106,873 Da
Also known as
3.2.1.207 · Alpha-glucosidase 2 · G2AN · Glucosidase II subunit alpha · KIAA0088

Resolves to

Protein
UniProtQ14697UniProt nameGANAB_HUMAN
Gene
HGNCHGNC:4138NCBI Gene23193GeneCardsGANAB
Pharmacology
KEGGhsa:23193
Structure
PDB8D43PDB8EMR
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neutral alpha-glucosidase AB, how selective are they, and which programs against it are still in active trials?

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