Explore a selection of our essential drug information below, or:
Identification
- Summary
Maltose is a sugar used as a sweetener and an inactive ingredient in drug products.
- Generic Name
- Maltose
- DrugBank Accession Number
- DB03323
- Background
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing (Grant & Hackh's Chemical Dictionary, 5th ed).
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Structure
Structure for Maltose (DB03323)
- Weight
- Average: 342.2965
Monoisotopic: 342.116211546 - Chemical Formula
- C12H22O11
- Synonyms
- D-(+)-maltose
- Maltose anhydrous
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Iron deficiency anemia (ida) Combination Product in combination with: Iron (DB01592) •••••••••••• •••••• Used in combination to treat Iron deficiency anemia (ida) Combination Product in combination with: Iron (DB01592) •••••••••••• •••••• - Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
Target Actions Organism UCyclomaltodextrin glucanotransferase Not Available Bacillus circulans UAlpha-amylase 2B Not Available Humans UBeta-amylase Not Available Bacillus cereus UMaltogenic alpha-amylase Not Available Geobacillus stearothermophilus UMaltodextrin phosphorylase Not Available Escherichia coli (strain K12) UMaltose-binding periplasmic protein Not Available Escherichia coli (strain K12) UAlpha-glucosidase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UMaltose binding protein Not Available Alicyclobacillus acidocaldarius UMalto-oligosyltrehalose trehalohydrolase Not Available Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- O-glycosyl compounds
- Alternative Parents
- Disaccharides / Oxanes / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Acetals / Primary alcohols / Hydrocarbon derivatives
- Substituents
- Acetal / Alcohol / Aliphatic heteromonocyclic compound / Disaccharide / Hemiacetal / Hydrocarbon derivative / O-glycosyl compound / Organoheterocyclic compound / Oxacycle / Oxane
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- glycosylglucose, maltooligosaccharide (CHEBI:17306) / Disaccharides (C00208)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 66Y63L379N
- CAS number
- 69-79-4
- InChI Key
- GUBGYTABKSRVRQ-PICCSMPSSA-N
- InChI
- InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11?,12-/m1/s1
- IUPAC Name
- (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-{[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxane-3,4,5-triol
- SMILES
- OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O
References
- Synthesis Reference
Chobe Yomoto, Takashi Adachi, Yutaka Nakajima, Hidemasa Hidaka, Tsukasa Yoshida, Fumio Sugawara, "Method for producing maltose." U.S. Patent US3998696, issued May, 1971.
US3998696- General References
- Not Available
- External Links
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Treatment Vascular Aging 1 somestatus stop reason just information to hide 3 Completed Treatment Bipolar Disorder (BD) / Depression, Bipolar 1 somestatus stop reason just information to hide 3 Completed Treatment Crohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Iron Deficiency Anemia (IDA) 1 somestatus stop reason just information to hide 1, 2 Not Yet Recruiting Treatment Cataracts / Glaucoma 1 somestatus stop reason just information to hide 1, 2 Suspended Treatment Cancer / Neoplasm / Tumor 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection Intravenous 10 % Injection Intravenous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 102-103 °C PhysProp water solubility 7.8E+005 mg/L (at 20 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) - Predicted Properties
Property Value Source Water Solubility 586.0 mg/mL ALOGPS logP -3 ALOGPS logP -4.7 Chemaxon logS 0.23 ALOGPS pKa (Strongest Acidic) 11.25 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 8 Chemaxon Polar Surface Area 189.53 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 68.34 m3·mol-1 Chemaxon Polarizability 31.57 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.8748 Blood Brain Barrier + 0.6207 Caco-2 permeable - 0.8836 P-glycoprotein substrate Non-substrate 0.5394 P-glycoprotein inhibitor I Non-inhibitor 0.7589 P-glycoprotein inhibitor II Non-inhibitor 0.9142 Renal organic cation transporter Non-inhibitor 0.8144 CYP450 2C9 substrate Non-substrate 0.8451 CYP450 2D6 substrate Non-substrate 0.8853 CYP450 3A4 substrate Non-substrate 0.658 CYP450 1A2 substrate Non-inhibitor 0.961 CYP450 2C9 inhibitor Non-inhibitor 0.9376 CYP450 2D6 inhibitor Non-inhibitor 0.9399 CYP450 2C19 inhibitor Non-inhibitor 0.9083 CYP450 3A4 inhibitor Non-inhibitor 0.9645 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8898 Ames test Non AMES toxic 0.8628 Carcinogenicity Non-carcinogens 0.9551 Biodegradation Not ready biodegradable 0.6632 Rat acute toxicity 1.0242 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9517 hERG inhibition (predictor II) Non-inhibitor 0.8283
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-01r5-0907000000-834cb065654acb2a5261 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-000f-2297000000-fe8f810a75c74c67fc24 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-02bg-2946000000-d2b885f3222fd86eccc8 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0ufu-4193000000-c5a67afae49d3c7e28f4 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0hti-9781000000-46fe030a29e7dd0e6297 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-9200000000-b450e922ea07c4fa67b4 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 158.94661 predictedDeepCCS 1.0 (2019) [M+H]+ 160.6571 predictedDeepCCS 1.0 (2019) [M+Na]+ 166.75664 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Bacillus circulans
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P30920
- Uniprot Name
- Cyclomaltodextrin glucanotransferase
- Molecular Weight
- 78046.265 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Alpha-amylase activity
- Gene Name
- AMY2B
- Uniprot ID
- P19961
- Uniprot Name
- Alpha-amylase 2B
- Molecular Weight
- 57709.49 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Bacillus cereus
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Not Available
- Gene Name
- spoII
- Uniprot ID
- P36924
- Uniprot Name
- Beta-amylase
- Molecular Weight
- 61628.585 Da
References
- Kind
- Protein
- Organism
- Geobacillus stearothermophilus
- Pharmacological action
- Unknown
- General Function
- Starch binding
- Specific Function
- Converts starch into maltose.
- Gene Name
- amyM
- Uniprot ID
- P19531
- Uniprot Name
- Maltogenic alpha-amylase
- Molecular Weight
- 78675.13 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known ...
- Gene Name
- malP
- Uniprot ID
- P00490
- Uniprot Name
- Maltodextrin phosphorylase
- Molecular Weight
- 90521.74 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
- Gene Name
- malE
- Uniprot ID
- P0AEX9
- Uniprot Name
- Maltose-binding periplasmic protein
- Molecular Weight
- 43387.235 Da
References
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
- Specific Function
- Alpha-glycosidase with a very broad specificity. Hydrolyzes maltose and other small maltooligosaccharides but is inactive against the polymeric substrate starch. AglA is not specific with respect t...
- Gene Name
- aglA
- Uniprot ID
- O33830
- Uniprot Name
- Alpha-glucosidase
- Molecular Weight
- 55046.815 Da
- Kind
- Protein
- Organism
- Alicyclobacillus acidocaldarius
- Pharmacological action
- Unknown
- General Function
- Maltose transmembrane transporter activity
- Specific Function
- Not Available
- Gene Name
- malE
- Uniprot ID
- Q9RHZ6
- Uniprot Name
- Maltose binding protein
- Molecular Weight
- 45673.62 Da
- Kind
- Protein
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Pharmacological action
- Unknown
- General Function
- Cation binding
- Specific Function
- Not Available
- Gene Name
- treZ
- Uniprot ID
- Q9RX51
- Uniprot Name
- Malto-oligosyltrehalose trehalohydrolase
- Molecular Weight
- 66909.235 Da
Drug created at June 13, 2005 13:24 / Updated at June 08, 2021 11:32