Sodium/glucose cotransporter 1

BE0004754ProteinHumansSLC5A1

Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. It is acted on by 14 drugs in DrugBank.

Gene name
SLC5A1
UniProtKB entry
P13866Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
664 residues · 73,497 Da
Also known as
High affinity sodium-glucose cotransporter · Na(+)/glucose cotransporter 1 · NAGT · SGLT1 · Solute carrier family 5 member 1

Resolves to

Protein
UniProtP13866UniProt nameSC5A1_HUMAN
Gene
HGNCHGNC:11036NCBI Gene6523GeneCardsSLC5A1
Pharmacology
IUPHAR/GtoPdb915KEGGhsa:6523
Structure
PDB7SL8PDB7SLAPDB7WMV
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/glucose cotransporter 1, how selective are they, and which programs against it are still in active trials?

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