Protein cereblon

Details

Name
Protein cereblon
Kind
protein
Synonyms
Not Available
Gene Name
CRBN
UniProtKB Entry
Q96SW2Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0008604|Protein cereblon
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
Number of residues
442
Molecular Weight
50545.375
Theoretical pI
Not Available
GO Classification
Functions
metal ion binding
Processes
proteasome-mediated ubiquitin-dependent protein catabolic process / protein ubiquitination
Components
Cul4A-RING E3 ubiquitin ligase complex / cytoplasm / membrane / nucleus
General Function
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2 (PubMed:33009960). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979, PubMed:24328678, PubMed:25043012, PubMed:25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:18414909, PubMed:29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (PubMed:18414909). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (PubMed:31620128)
Specific Function
Metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0017526|Protein cereblon (CRBN)
ATGGCCGGCGAAGGAGATCAGCAGGACGCTGCGCACAACATGGGCAACCACCTGCCGCTC
CTGCCTGAGAGTGAGGAAGAAGATGAAATGGAAGTTGAAGACCAGGATAGTAAAGAAGCC
AAAAAACCAAACATCATAAATTTTGACACCAGTCTGCCGACATCACATACATACCTAGGT
GCTGATATGGAAGAATTTCATGGCAGGACTTTGCACGATGACGACAGCTGTCAGGTGATT
CCAGTTCTTCCACAAGTGATGATGATCCTGATTCCCGGACAGACATTACCTCTTCAGCTT
TTTCACCCTCAAGAAGTCAGTATGGTGCGGAATTTAATTCAGAAAGATAGAACCTTTGCT
GTTCTTGCATACAGCAATGTACAGGAAAGGGAAGCACAGTTTGGAACAACAGCAGAGATA
TATGCCTATCGAGAAGAACAGGATTTTGGAATTGAGATAGTGAAAGTGAAAGCAATTGGA
AGACAAAGGTTCAAAGTCCTTGAGCTAAGAACACAGTCAGATGGAATCCAGCAAGCTAAA
GTGCAAATTCTTCCCGAATGTGTGTTGCCTTCAACCATGTCTGCAGTTCAATTAGAATCC
CTCAATAAGTGCCAGATATTTCCTTCAAAACCTGTCTCAAGAGAAGACCAATGTTCATAT
AAATGGTGGCAGAAATACCAGAAGAGAAAGTTTCATTGTGCAAATCTAACTTCATGGCCT
CGCTGGCTGTATTCCTTATATGATGCTGAGACCTTAATGGACAGAATCAAGAAACAGCTA
CGTGAATGGGATGAAAATCTAAAAGATGATTCTCTTCCTTCAAATCCAATAGATTTTTCT
TACAGAGTAGCTGCTTGTCTTCCTATTGATGATGTATTGAGAATTCAGCTCCTTAAAATT
GGCAGTGCTATCCAGCGACTTCGCTGTGAATTAGACATTATGAATAAATGTACTTCCCTT
TGCTGTAAACAATGTCAAGAAACAGAAATAACAACCAAAAATGAAATATTCAGTTTATCC
TTATGTGGGCCGATGGCAGCTTATGTGAATCCTCATGGATATGTGCATGAGACACTTACT
GTGTATAAGGCTTGCAACTTGAATCTGATAGGCCGGCCTTCTACAGAACACAGCTGGTTT
CCTGGGTATGCCTGGACTGTTGCCCAGTGTAAGATCTGTGCAAGCCATATTGGATGGAAG
TTTACGGCCACCAAAAAAGACATGTCACCTCAAAAATTTTGGGGCTTAACGCGATCTGCT
CTGTTGCCCACGATCCCAGACACTGAAGATGAAATAAGTCCAGACAAAGTAATACTTTGC
TTGTAA
Chromosome Location
3
Locus
3p26.2
External Identifiers
ResourceLink
UniProtKB IDQ96SW2
UniProtKB Entry NameCRBN_HUMAN
GeneCard IDCRBN
HGNC IDHGNC:30185
PDB ID(s)4M91, 4TZ4, 5FQD, 5HXB, 5V3O, 6BN7, 6BN8, 6BN9, 6BNB, 6BOY, 6H0F, 6H0G, 6UML, 6XK9, 7BQU, 7BQV, 7LPS, 7U8F, 8CVP, 8D7U, 8D7V, 8D7W, 8D7X, 8D7Y, 8D7Z, 8D80, 8D81, 8DEY, 8G66, 8OIZ, 8OJH, 8TNP, 8TNQ, 8TNR, 8U15, 8U16, 8U17
KEGG IDhsa:51185
IUPHAR/Guide To Pharmacology ID3086
NCBI Gene ID51185
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
PomalidomideapprovedyestargetinhibitorDetails
Thalidomideapproved, investigational, withdrawnyestargetinhibitorDetails
LenalidomideapprovedyestargetinhibitorDetails
AvadomideinvestigationalyestargetmodulatorDetails
IberdomideinvestigationalyestargetinhibitorDetails