Protein cereblon

BE0004755ProteinHumansCRBN

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2, GLUL, IKZF1 and CSNK1A1 (PubMed:26990986, PubMed:33009960, PubMed:41565821). It is acted on by 8 drugs in DrugBank.

Gene name
CRBN
UniProtKB entry
Q96SW2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
442 residues · 50,545 Da

Resolves to

Protein
UniProtQ96SW2UniProt nameCRBN_HUMAN
Gene
HGNCHGNC:30185NCBI Gene51185GeneCardsCRBN
Pharmacology
IUPHAR/GtoPdb3086KEGGhsa:51185
Structure
PDB10AYPDB11MRPDB4M91
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein cereblon, how selective are they, and which programs against it are still in active trials?

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