Receptor tyrosine-protein kinase erbB-4

BE0004772ProteinHumansERBB4

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation,... It is acted on by 11 drugs in DrugBank.

Gene name
ERBB4
UniProtKB entry
Q15303Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,308 residues · 146,807 Da
Also known as
2.7.10.1 · HER4 · p180erbB4 · Proto-oncogene-like protein c-ErbB-4 · Tyrosine kinase-type cell surface receptor HER4

Resolves to

Protein
UniProtQ15303UniProt nameERBB4_HUMAN
Gene
HGNCHGNC:3432NCBI Gene2066GeneCardsERBB4
Pharmacology
IUPHAR/GtoPdb1799KEGGhsa:2066
Structure
PDB2AHXPDB2L2TPDB2LCX
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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14Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor tyrosine-protein kinase erbB-4, how selective are they, and which programs against it are still in active trials?

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