Ryanodine receptor 2

BE0005295ProteinHumansRYR2

Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. It is acted on by 8 drugs in DrugBank.

Gene name
RYR2
UniProtKB entry
Q92736Swiss-Prot
Cellular location
Sarcoplasmic reticulum membrane
Residues / weight
4,967 residues · 564,563 Da
Also known as
Cardiac muscle ryanodine receptor · Cardiac muscle ryanodine receptor-calcium release channel · hRYR-2 · RYR-2 · RyR2

Resolves to

Protein
UniProtQ92736UniProt nameRYR2_HUMAN
Gene
HGNCHGNC:10484NCBI Gene6262GeneCardsRYR2
Pharmacology
IUPHAR/GtoPdb748KEGGhsa:6262
Structure
PDB4JKQPDB6Y4OPDB6Y4P
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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50GO termsFunction, process and component, as structured annotations
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10Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ryanodine receptor 2, how selective are they, and which programs against it are still in active trials?

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