Sterol regulatory element-binding protein 1

BE0005540ProteinHumansSREBF1

Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). It is acted on by 4 drugs in DrugBank.

Gene name
SREBF1
UniProtKB entry
P36956Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,147 residues · 121,674 Da
Also known as
BHLHD1 · Class D basic helix-loop-helix protein 1 · SREBP-1 · SREBP1 · Sterol regulatory element-binding transcription factor 1

Resolves to

Protein
UniProtP36956UniProt nameSRBP1_HUMAN
Gene
HGNCHGNC:11289NCBI Gene6720GeneCardsSREBF1
Pharmacology
KEGGhsa:6720
Structure
PDB1AM9
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sterol regulatory element-binding protein 1, how selective are they, and which programs against it are still in active trials?

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