Omega-3-acid ethyl esters is a mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia. Omega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand name Lovaza.
- Mechanism
- Curator reviewed · 3 references
Omega-3-acid ethyl esters reduce triglyceride production by the liver but this mechanism is not well understood. Omega-3-acid ethyl esters inhibit acyl-CoA:1,2-diacylglycerol acyltransferase, reducing triglyceride synthesis and increasing paroxysmal beta-oxidation, which increases fatty aside metabolism. Omega-3-acid ethyl esters also inhibit the release of fatty acids by competing for enzymes involved in the synthesis of triglycerides, increase triglyceride clearance by increasing the activity of lipoprotein lipase, and decrease production of VLDL-C.
- Primary indication
- Omega-3-Acid Ethyl Esters capsules, USP are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia (HTG).Curator reviewed · 1 structured indication
- First approval
- United States, 2007
- Also known as
- omega-3 acid ethyl esters · Omega-3 fatty acid ethyl esters
- Code names
- K-85 · TAK-085
- Brand names
Resolves to
What you can answer from here — as of December 12, 2025
Which drugs share a target with Omega-3-acid ethyl esters, and which of those have an active Phase 3 trial?
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