Proprotein convertase subtilisin/kexin type 9

BE0008643ProteinHumansPCSK9

Crucial player in the regulation of plasma cholesterol homeostasis. It is acted on by 12 drugs in DrugBank.

Gene name
PCSK9
UniProtKB entry
Q8NBP7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
692 residues · 74,286 Da
Also known as
3.4.21.- · NARC-1 · NARC1 · Neural apoptosis-regulated convertase 1 · PC9

Resolves to

Protein
UniProtQ8NBP7UniProt namePCSK9_HUMAN
Gene
HGNCHGNC:20001NCBI Gene255738GeneCardsPCSK9
Pharmacology
IUPHAR/GtoPdb2388KEGGhsa:255738
Structure
PDB2P4EPDB2PMWPDB2QTW
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
37GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
76+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Proprotein convertase subtilisin/kexin type 9, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In