Carbapenem-hydrolyzing beta-lactamase KPC-2

BE0008649ProteinKlebsiella pneumoniaeKPC-2

Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency. It is acted on by 9 drugs in DrugBank.

Gene name
KPC-2
UniProtKB entry
Q9F663Swiss-Prot
Residues / weight
293 residues · 31,115 Da
Also known as
3.5.2.6 · bla · Carbapenem-hydrolyzing beta-lactamase KPC · Carbapenem-hydrolyzing beta-lactamase KPC-1 · kpc

Resolves to

Protein
UniProtQ9F663UniProt nameBLKPC_KLEPN
Gene
NCBI Gene13914015
Pharmacology
KEGGag:AAG13410
Structure
PDB2OV5PDB3E2KPDB3E2L
Drugs

What you can answer from here — as of May 03, 2025

9DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbapenem-hydrolyzing beta-lactamase KPC-2, how selective are they, and which programs against it are still in active trials?

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