Sphingosine 1-phosphate receptor 1

BE0008652ProteinHumansS1PR1

G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. It is acted on by 14 drugs in DrugBank.

Gene name
S1PR1
UniProtKB entry
P21453Swiss-Prot
Cellular location
Cell membrane
Residues / weight
382 residues · 42,810 Da
Also known as
CHEDG1 · EDG1 · Endothelial differentiation G protein-coupled receptor 1 · S1P receptor 1 · S1P receptor Edg-1

Resolves to

Protein
UniProtP21453UniProt nameS1PR1_HUMAN
Gene
HGNCHGNC:3165NCBI Gene1901GeneCardsS1PR1
Pharmacology
IUPHAR/GtoPdb275KEGGhsa:1901
Structure
PDB3V2WPDB3V2YPDB7EO2
Drugs

What you can answer from here — as of September 03, 2024

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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80+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine 1-phosphate receptor 1, how selective are they, and which programs against it are still in active trials?

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