Natural resistance-associated macrophage protein 2

BE0008685ProteinHumansSLC11A2

Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917, PubMed:39824808). It is acted on by 9 drugs in DrugBank.

Gene name
SLC11A2
UniProtKB entry
P49281Swiss-Prot
Cellular location
Early endosome membrane
Residues / weight
568 residues · 62,265 Da
Also known as
DCT1 · Divalent cation transporter 1 · Divalent metal transporter 1 · DMT-1 · DMT1

Resolves to

Protein
UniProtP49281UniProt nameNRAM2_HUMAN
Gene
HGNCHGNC:10908NCBI Gene4891GeneCardsSLC11A2
Pharmacology
IUPHAR/GtoPdb967KEGGhsa:4891
Structure
PDB5F0LPDB5F0MPDB5F0P
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Natural resistance-associated macrophage protein 2, how selective are they, and which programs against it are still in active trials?

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