Calmodulin-3

Details

Name
Calmodulin-3
Kind
protein
Synonyms
  • CALML2
  • CAM3
  • CAMC
  • CAMIII
Gene Name
CALM3
UniProtKB Entry
P0DP25Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0051311|Calmodulin-3
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues
149
Molecular Weight
16837.47
Theoretical pI
Not Available
GO Classification
Functions
adenylate cyclase activator activity / adenylate cyclase binding / calcium-dependent protein binding / protein kinase binding / protein phosphatase activator activity / protein serine/threonine kinase activator activity / titin binding / transmembrane transporter binding
Processes
detection of calcium ion / G protein-coupled receptor signaling pathway / G2/M transition of mitotic cell cycle / negative regulation of calcium ion export across plasma membrane / negative regulation of high voltage-gated calcium channel activity / negative regulation of peptidyl-threonine phosphorylation / negative regulation of ryanodine-sensitive calcium-release channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of phosphoprotein phosphatase activity / positive regulation of protein autophosphorylation / positive regulation of protein dephosphorylation / positive regulation of protein serine/threonine kinase activity / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of calcium-mediated signaling / regulation of cardiac muscle cell action potential / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of cell communication by electrical coupling involved in cardiac conduction / regulation of cytokinesis / regulation of heart rate / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / response to calcium ion / substantia nigra development
Components
calcium channel complex / catalytic complex / centrosome / myelin sheath / nucleus / plasma membrane / protein-containing complex / sarcomere / sperm midpiece / spindle microtubule / vesicle / voltage-gated potassium channel complex
General Function
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425)
Specific Function
adenylate cyclase activator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton, spindle
Gene sequence
Not Available
Chromosome Location
19
Locus
19q13.32
External Identifiers
ResourceLink
UniProtKB IDP0DP25
UniProtKB Entry NameCALM3_HUMAN
GeneCard IDCALM3
HGNC IDHGNC:1449
PDB ID(s)5COC, 5J03, 6K67, 7BYL, 7BYM, 7BYN, 7CR3, 7CR4, 7CR7, 7VNP, 7VNQ, 7VNR, 7XNI, 7XNK, 7XNL, 7XNN, 8BD2
KEGG IDhsa:808
NCBI Gene ID808
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Calcium citrateapproved, investigationalunknowntargetagonistDetails
Calcium PhosphateapprovedunknowntargetagonistDetails
Calcium phosphate dihydrateapprovedunknowntargetDetails
tert-butanolexperimentalyestargetinhibitorDetails
TrimethyllysineexperimentalyestargetinhibitorDetails
Myristic acidexperimentalyestargetinhibitorDetails
AcetateexperimentalyestargetinhibitorDetails
Trifluoperazineapproved, investigationalyestargetinhibitorDetails
AprindineexperimentalyestargetinhibitorDetails
HalofantrineapprovedyestargetmodulatorDetails