ATP synthase F(0) complex subunit a

BE0009014ProteinHumansMT-ATP6

Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron... It is acted on by 6 drugs in DrugBank.

Gene name
MT-ATP6
UniProtKB entry
P00846Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
226 residues · 24,817 Da
Also known as
ATP6 · ATPASE6 · F-ATPase protein 6 · MTATP6 · Proton-conducting channel, ATP synthase F(0) complex subunit a

Resolves to

Protein
UniProtP00846UniProt nameATP6_HUMAN
Gene
HGNCHGNC:7414NCBI Gene4508GeneCardsMT-ATP6
Pharmacology
KEGGhsa:4508
Structure
PDB8H9FPDB8H9JPDB8H9M
Drugs

What you can answer from here — as of June 26, 2025

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP synthase F(0) complex subunit a, how selective are they, and which programs against it are still in active trials?

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