Beclin-1

BE0009015ProteinHumansBECN1

Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). It is acted on by 6 drugs in DrugBank.

Gene name
BECN1
UniProtKB entry
Q14457Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
450 residues · 51,896 Da
Also known as
Coiled-coil myosin-like BCL2-interacting protein · GT197 · Protein GT197

Resolves to

Protein
UniProtQ14457UniProt nameBECN1_HUMAN
Gene
HGNCHGNC:1034NCBI Gene8678GeneCardsBECN1
Pharmacology
KEGGhsa:8678
Structure
PDB13BVPDB2P1LPDB2PON
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beclin-1, how selective are they, and which programs against it are still in active trials?

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