Tyrosine-protein kinase TXK

BE0009403ProteinHumansTXK

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. It is acted on by 4 drugs in DrugBank.

Gene name
TXK
UniProtKB entry
P42681Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
527 residues · 61,258 Da
Also known as
2.7.10.2 · Protein-tyrosine kinase 4 · PTK4 · Resting lymphocyte kinase · RLK

Resolves to

Protein
UniProtP42681UniProt nameTXK_HUMAN
Gene
HGNCHGNC:12434NCBI Gene7294GeneCardsTXK
Pharmacology
IUPHAR/GtoPdb2268KEGGhsa:7294
Structure
PDB2DM0
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase TXK, how selective are they, and which programs against it are still in active trials?

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