AP2-associated protein kinase 1

BE0009409ProteinHumansAAK1

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931,... It is acted on by 3 drugs in DrugBank.

Gene name
AAK1
UniProtKB entry
Q2M2I8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
961 residues · 103,884 Da
Also known as
2.7.11.1 · Adaptor-associated kinase 1 · KIAA1048

Resolves to

Protein
UniProtQ2M2I8UniProt nameAAK1_HUMAN
Gene
HGNCHGNC:19679NCBI Gene22848GeneCardsAAK1
Pharmacology
IUPHAR/GtoPdb1921KEGGhsa:22848
Structure
PDB4WSQPDB5L4QPDB5TE0
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on AP2-associated protein kinase 1, how selective are they, and which programs against it are still in active trials?

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