Cytoplasmic tyrosine-protein kinase BMX

BE0009416ProteinHumansBMX

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. It is acted on by 4 drugs in DrugBank.

Gene name
BMX
UniProtKB entry
P51813Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
675 residues · 78,010 Da
Also known as
2.7.10.2 · Bone marrow tyrosine kinase gene in chromosome X protein · Epithelial and endothelial tyrosine kinase · ETK · NTK38

Resolves to

Protein
UniProtP51813UniProt nameBMX_HUMAN
Gene
HGNCHGNC:1079NCBI Gene660GeneCardsBMX
Pharmacology
IUPHAR/GtoPdb1942KEGGhsa:660
Structure
PDB2EKXPDB2YS2PDB3SXR
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytoplasmic tyrosine-protein kinase BMX, how selective are they, and which programs against it are still in active trials?

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