Casein kinase I isoform alpha

BE0009427ProteinHumansCSNK1A1

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It is acted on by 4 drugs in DrugBank.

Gene name
CSNK1A1
UniProtKB entry
P48729Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
337 residues · 38,915 Da
Also known as
2.7.11.1 · CK1 · CKI-alpha

Resolves to

Protein
UniProtP48729UniProt nameKC1A_HUMAN
Gene
HGNCHGNC:2451NCBI Gene1452GeneCardsCSNK1A1
Pharmacology
IUPHAR/GtoPdb1995KEGGhsa:1452
Structure
PDB5FQDPDB6GZDPDB7WTT
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Casein kinase I isoform alpha, how selective are they, and which programs against it are still in active trials?

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