Ephrin type-A receptor 1

BE0009436ProteinHumansEPHA1

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 1 drug in DrugBank.

Gene name
EPHA1
UniProtKB entry
P21709Swiss-Prot
Cellular location
Cell membrane
Residues / weight
976 residues · 108,126 Da
Also known as
2.7.10.1 · EPH · EPH tyrosine kinase · EPH tyrosine kinase 1 · EPHT

Resolves to

Protein
UniProtP21709UniProt nameEPHA1_HUMAN
Gene
HGNCHGNC:3385NCBI Gene2041GeneCardsEPHA1
Pharmacology
IUPHAR/GtoPdb1821KEGGhsa:2041
Structure
PDB2K1KPDB2K1LPDB3HIL
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 1, how selective are they, and which programs against it are still in active trials?

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