Ephrin type-A receptor 1

Details

Name
Ephrin type-A receptor 1
Kind
protein
Synonyms
  • 2.7.10.1
  • EPH
  • EPH tyrosine kinase
  • EPH tyrosine kinase 1
  • EPHT
  • EPHT1
  • Erythropoietin-producing hepatoma receptor
  • hEpha1
  • Tyrosine-protein kinase receptor EPH
Gene Name
EPHA1
UniProtKB Entry
P21709Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0051750|Ephrin type-A receptor 1
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNG
TPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKE
TFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRG
LYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPR
PSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQ
STAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGG
RQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVE
AQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLT
YELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVS
RGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYV
DLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKD
TSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQ
LVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGT
YETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIE
DGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRM
TLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITL
PGHQKRILCSIQGFKD
Number of residues
976
Molecular Weight
108126.305
Theoretical pI
Not Available
GO Classification
Functions
fibronectin binding / transmembrane receptor protein tyrosine kinase activity
Processes
positive regulation of cell population proliferation
Components
receptor complex
General Function
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
1-25
Transmembrane Regions
548-568
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0051751|Ephrin type-A receptor 1 (EPHA1)
ATGGAGCGGCGCTGGCCCCTGGGGCTAGGGCTGGTGCTGCTGCTCTGCGCCCCGCTGCCC
CCGGGGGCGCGCGCCAAGGAAGTTACTCTGATGGACACAAGCAAGGCACAGGGAGAGCTG
GGCTGGCTGCTGGATCCCCCAAAAGATGGGTGGAGTGAACAGCAACAGATACTGAATGGG
ACACCCCTGTACATGTACCAGGACTGCCCAATGCAAGGACGCAGAGACACTGACCACTGG
CTTCGCTCCAATTGGATCTACCGCGGGGAGGAGGCTTCCCGCGTCCACGTGGAGCTGCAG
TTCACCGTGCGGGACTGCAAGAGTTTCCCTGGGGGAGCCGGGCCTCTGGGCTGCAAGGAG
ACCTTCAACCTTCTGTACATGGAGAGTGACCAGGATGTGGGCATTCAGCTCCGACGGCCC
TTGTTCCAGAAGGTAACCACGGTGGCTGCAGACCAGAGCTTCACCATTCGAGACCTTGTG
TCTGGCTCCGTGAAGCTGAATGTGGAGCGCTGCTCTCTGGGCCGCCTGACCCGCCGTGGC
CTCTACCTCGCTTTCCACAACCCGGGTGCCTGTGTGGCCCTGGTGTCTGTCCGGGTCTTC
TACCAGCGCTGTCCTGAGACCCTGAATGGCTTGGCCCAATTCCCAGACACTCTGCCTGGC
CCCGCTGGGTTGGTGGAAGTGGCGGGGACCTGCTTGCCCCACGCGCGGGCCAGCCCCAGG
CCCTCAGGTGCACCCCGCATGCACTGCAGCCCTGATGGCGAGTGGCTGGTGCCTGTAGGA
CGGTGCCACTGTGAGCCTGGCTATGAGGAAGGTGGCAGTGGCGAAGCATGTGTTGCCTGC
CCTAGCGGCTCCTACCGGATGGACATGGACACACCCCATTGTCTCACGTGCCCCCAGCAG
AGCACTGCTGAGTCTGAGGGGGCCACCATCTGTACCTGTGAGAGCGGCCATTACAGAGCT
CCCGGGGAGGGCCCCCAGGTGGCATGCACAGGTCCCCCCTCGGCCCCCCGAAACCTGAGC
TTCTCTGCCTCAGGGACTCAGCTCTCCCTGCGTTGGGAACCCCCAGCAGATACGGGGGGA
CGCCAGGATGTCAGATACAGTGTGAGGTGTTCCCAGTGTCAGGGCACAGCACAGGACGGG
GGGCCCTGCCAGCCCTGTGGGGTGGGCGTGCACTTCTCGCCGGGGGCCCGGGGGCTCACC
ACACCTGCAGTGCATGTCAATGGCCTTGAACCTTATGCCAACTACACCTTTAATGTGGAA
GCCCAAAATGGAGTGTCAGGGCTGGGCAGCTCTGGCCATGCCAGCACCTCAGTCAGCATC
AGCATGGGGCATGCAGAGTCACTGTCAGGCCTGTCTCTGAGACTGGTGAAGAAAGAACCG
AGGCAACTAGAGCTGACCTGGGCGGGGTCCCGGCCCCGAAGCCCTGGGGCGAACCTGACC
TATGAGCTGCACGTGCTGAACCAGGATGAAGAACGGTACCAGATGGTTCTAGAACCCAGG
GTCTTGCTGACAGAGCTGCAGCCTGACACCACATACATCGTCAGAGTCCGAATGCTGACC
CCACTGGGTCCTGGCCCTTTCTCCCCTGATCATGAGTTTCGGACCAGCCCACCAGTGTCC
AGGGGCCTGACTGGAGGAGAGATTGTAGCCGTCATCTTTGGGCTGCTGCTTGGTGCAGCC
TTGCTGCTTGGGATTCTCGTTTTCCGGTCCAGGAGAGCCCAGCGGCAGAGGCAGCAGAGG
CAGCGTGACCGCGCCACCGATGTGGATCGAGAGGACAAGCTGTGGCTGAAGCCTTATGTG
GACCTCCAGGCATACGAGGACCCTGCACAGGGAGCCCTGGACTTTACCCGGGAGCTTGAT
CCAGCGTGGCTGATGGTGGACACTGTCATAGGAGAAGGAGAGTTTGGGGAAGTGTATCGA
GGGACCCTGAGGCTCCCCAGCCAGGACTGCAAGACTGTGGCCATTAAGACCTTAAAAGAC
ACATCCCCAGGTGGCCAGTGGTGGAACTTCCTTCGAGAGGCAACTATCATGGGCCAGTTT
AGCCACCCGCATATTCTGCATCTGGAAGGCGTCGTCACAAAGCGAAAGCCGATCATGATC
ATCACAGAATTTATGGAGAATGGAGCCCTGGATGCCTTCCTGAGGGAGCGGGAGGACCAG
CTGGTCCCTGGGCAGCTAGTGGCCATGCTGCAGGGCATAGCATCTGGCATGAACTACCTC
AGTAATCACAATTATGTCCACCGGGACCTGGCTGCCAGAAACATCTTGGTGAATCAAAAC
CTGTGCTGCAAGGTGTCTGACTTTGGCCTGACTCGCCTCCTGGATGACTTTGATGGCACA
TACGAAACCCAGGGAGGAAAGATCCCTATCCGTTGGACAGCCCCTGAAGCCATTGCCCAT
CGGATCTTCACCACAGCCAGCGATGTGTGGAGCTTTGGGATTGTGATGTGGGAGGTGCTG
AGCTTTGGGGACAAGCCTTATGGGGAGATGAGCAATCAGGAGGTTATGAAGAGCATTGAG
GATGGGTACCGGTTGCCCCCTCCTGTGGACTGCCCTGCCCCTCTGTATGAGCTCATGAAG
AACTGCTGGGCATATGACCGTGCCCGCCGGCCACACTTCCAGAAGCTTCAGGCACATCTG
GAGCAACTGCTTGCCAACCCCCACTCCCTGCGGACCATTGCCAACTTTGACCCCAGGATG
ACTCTTCGCCTGCCCAGCCTGAGTGGCTCAGATGGGATCCCATATCGAACCGTCTCTGAG
TGGCTCGAGTCCATACGCATGAAACGCTACATCCTGCACTTCCACTCGGCTGGGCTGGAC
ACCATGGAGTGTGTGCTGGAGCTGACCGCTGAGGACCTGACGCAGATGGGAATCACACTG
CCCGGGCACCAGAAGCGCATTCTTTGCAGTATTCAGGGATTCAAGGACTGA
Chromosome Location
7
Locus
7q34-q35
External Identifiers
ResourceLink
UniProtKB IDP21709
UniProtKB Entry NameEPHA1_HUMAN
GeneCard IDEPHA1
HGNC IDHGNC:3385
PDB ID(s)2K1K, 2K1L, 3HIL, 3KKA
KEGG IDhsa:2041
IUPHAR/Guide To Pharmacology ID1821
NCBI Gene ID2041
General References
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  7. Authors unspecified: Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell. 1997 Aug 8;90(3):403-4. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Fostamatinibapproved, investigationalunknowntargetinhibitorDetails