Interleukin-1 receptor-associated kinase 1

BE0009452ProteinHumansIRAK1

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. It is acted on by 4 drugs in DrugBank.

Gene name
IRAK1
UniProtKB entry
P51617Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
712 residues · 76,536 Da
Also known as
2.7.11.1 · IRAK · IRAK-1

Resolves to

Protein
UniProtP51617UniProt nameIRAK1_HUMAN
Gene
HGNCHGNC:6112NCBI Gene3654GeneCardsIRAK1
Pharmacology
IUPHAR/GtoPdb2042KEGGhsa:3654
Structure
PDB6BFN
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-1 receptor-associated kinase 1, how selective are they, and which programs against it are still in active trials?

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