Dual specificity mitogen-activated protein kinase kinase 6
Details
- Name
- Dual specificity mitogen-activated protein kinase kinase 6
- Kind
- protein
- Synonyms
- 2.7.12.2
- MAP kinase kinase 6
- MAPK/ERK kinase 6
- MAPKK 6
- MEK 6
- MEK6
- MKK6
- PRKMK6
- SAPK kinase 3
- SAPKK-3
- SAPKK3
- SKK3
- Stress-activated protein kinase kinase 3
- Gene Name
- MAP2K6
- UniProtKB Entry
- P52564Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0051800|Dual specificity mitogen-activated protein kinase kinase 6 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
- Number of residues
- 334
- Molecular Weight
- 37492.055
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / identical protein binding / MAP kinase kinase activity / protein kinase binding / protein serine/threonine kinase activity / protein tyrosine kinase activityProcessesapoptotic process / cardiac muscle contraction / cellular response to sorbitol / ovulation cycle process / positive regulation of apoptotic process / positive regulation of nitric-oxide synthase biosynthetic process / positive regulation of prostaglandin secretion / response to ischemia / signal transduction / stress-activated protein kinase signaling cascadeComponentscytoplasm / cytoskeleton / cytosol / nucleoplasm
- General Function
- Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases
- Specific Function
- ATP binding
- Pfam Domain Function
- Pkinase (PF00069)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0051801|Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) ATGTCTCAGTCGAAAGGCAAGAAGCGAAACCCTGGCCTTAAAATTCCAAAAGAAGCATTT GAACAACCTCAGACCAGTTCCACACCACCTCGAGATTTAGACTCCAAGGCTTGCATTTCT ATTGGAAATCAGAACTTTGAGGTGAAGGCAGATGACCTGGAGCCTATAATGGAACTGGGA CGAGGTGCGTACGGGGTGGTGGAGAAGATGCGGCACGTGCCCAGCGGGCAGATCATGGCA GTGAAGCGGATCCGAGCCACAGTAAATAGCCAGGAACAGAAACGGCTACTGATGGATTTG GATATTTCCATGAGGACGGTGGACTGTCCATTCACTGTCACCTTTTATGGCGCACTGTTT CGGGAGGGTGATGTGTGGATCTGCATGGAGCTCATGGATACATCACTAGATAAATTCTAC AAACAAGTTATTGATAAAGGCCAGACAATTCCAGAGGACATCTTAGGGAAAATAGCAGTT TCTATTGTAAAAGCATTAGAACATTTACATAGTAAGCTGTCTGTCATTCACAGAGACGTC AAGCCTTCTAATGTACTCATCAATGCTCTCGGTCAAGTGAAGATGTGCGATTTTGGAATC AGTGGCTACTTGGTGGACTCTGTTGCTAAAACAATTGATGCAGGTTGCAAACCATACATG GCCCCTGAAAGAATAAACCCAGAGCTCAACCAGAAGGGATACAGTGTGAAGTCTGACATT TGGAGTCTGGGCATCACGATGATTGAGTTGGCCATCCTTCGATTTCCCTATGATTCATGG GGAACTCCATTTCAGCAGCTCAAACAGGTGGTAGAGGAGCCATCGCCACAACTCCCAGCA GACAAGTTCTCTGCAGAGTTTGTTGACTTTACCTCACAGTGCTTAAAGAAGAATTCCAAA GAACGGCCTACATACCCAGAGCTAATGCAACATCCATTTTTCACCCTACATGAATCCAAA GGAACAGATGTGGCATCTTTTGTAAAACTGATTCTTGGAGACTAA
- Chromosome Location
- 17
- Locus
- 17q24.3
- External Identifiers
Resource Link UniProtKB ID P52564 UniProtKB Entry Name MP2K6_HUMAN GeneCard ID MAP2K6 HGNC ID HGNC:6846 PDB ID(s) 2Y8O, 3ENM, 3FME, 3VN9, 5ETF, 8A8M, 8P7J, 8PM3 KEGG ID hsa:5608 IUPHAR/Guide To Pharmacology ID 2067 NCBI Gene ID 5608 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Fostamatinib approved, investigational unknown target inhibitor Details