Serine/threonine-protein kinase PAK 1

BE0009505ProteinHumansPAK1

Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197,... It is acted on by 5 drugs in DrugBank.

Gene name
PAK1
UniProtKB entry
Q13153Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
545 residues · 60,646 Da
Also known as
2.7.11.1 · Alpha-PAK · p21-activated kinase 1 · p65-PAK · PAK-1

Resolves to

Protein
UniProtQ13153UniProt namePAK1_HUMAN
Gene
HGNCHGNC:8590NCBI Gene5058GeneCardsPAK1
Pharmacology
IUPHAR/GtoPdb2133KEGGhsa:5058
Structure
PDB1F3MPDB1YHVPDB1YHW
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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43GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PAK 1, how selective are they, and which programs against it are still in active trials?

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