N-sulphoglucosamine sulphohydrolase

BE0009785ProteinHumansSGSH

Catalyzes a step in lysosomal heparan sulfate degradation. It is acted on by 2 drugs in DrugBank.

Gene name
SGSH
UniProtKB entry
P51688Swiss-Prot
Cellular location
Lysosome
Residues / weight
502 residues · 56,695 Da
Also known as
3.10.1.1 · HSS · Sulfoglucosamine sulfamidase · Sulphamidase

Resolves to

Protein
UniProtP51688UniProt nameSPHM_HUMAN
Gene
HGNCHGNC:10818NCBI Gene6448GeneCardsSGSH
Pharmacology
KEGGhsa:6448
Structure
PDB4MHXPDB4MIV
Drugs

What you can answer from here — as of September 26, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which compounds in development act on N-sulphoglucosamine sulphohydrolase, and which indications are they being tested in?

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