An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

Article Details

Citation
Copy to clipboard

Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22.

PubMed ID
24275569 [ View in PubMed
]
Abstract

Protein phosphorylation is one of the most common post-translational modifications. It plays key roles in regulating diverse biological processes of liver tissues. To better understand the role of protein phosphorylation in liver functions, it is essential to perform in-depth phosphoproteome analysis of human liver. Here, an enzyme assisted reversed-phase-reversed-phase liquid chromatography (RP-RPLC) approach with both RPLC separations operated with optimized acidic mobile phase was developed. High orthogonal separation was achieved by trypsin digestion of the Glu-C generated peptides in the fractions collected from the first RPLC separation. The phosphoproteome coverage was further improved by using two types of instruments, i.e. TripleTOF 5600 and LTQ Orbitrap Velos. A total of 22,446 phosphorylation sites, corresponding to 6526 nonredundant phosphoproteins were finally identified from normal human liver tissues. Of these sites, 15,229 sites were confidently localized with Ascore>/=13. This dataset was the largest phosphoproteome dataset of human liver. It can be a public resource for the liver research community and holds promise for further biology studies. BIOLOGICAL SIGNIFICANCE: The enzyme assisted approach enabled the two RPLC separations operated both with optimized acidic mobile phases. The identifications from TripleTOF 5600 and Orbitrap Velos are highly complementary. The largest phosphoproteome dataset of human liver was generated.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Glutaminase liver isoform, mitochondrialQ9UI32Details
17-beta-hydroxysteroid dehydrogenase type 2P37059Details
Glycogen phosphorylase, liver formP06737Details
NAD(P) transhydrogenase, mitochondrialQ13423Details
Alcohol dehydrogenase class-3P11766Details
Aminomethyltransferase, mitochondrialP48728Details
Tyrosine-protein kinase ABL1P00519Details
Collagen alpha-1(I) chainP02452Details
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialP56181Details
7-dehydrocholesterol reductaseQ9UBM7Details
Dehydrogenase/reductase SDR family member 4Q9BTZ2Details
Insulin receptorP06213Details
RAF proto-oncogene serine/threonine-protein kinaseP04049Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialO00217Details
TransketolaseP29401Details
Pyridoxal kinaseO00764Details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingQ15738Details
Pyruvate kinase PKLRP30613Details
ProthrombinP00734Details
High affinity immunoglobulin epsilon receptor subunit gammaP30273Details
Delta-aminolevulinic acid dehydrataseP13716Details
Prolyl 4-hydroxylase subunit alpha-1P13674Details
Serine--tRNA ligase, cytoplasmicP49591Details
L-lactate dehydrogenase B chainP07195Details
Acetyl-CoA acetyltransferase, mitochondrialP24752Details
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialQ9HCC0Details
Alpha-aminoadipic semialdehyde synthase, mitochondrialQ9UDR5Details
Growth hormone receptorP10912Details
SEC14-like protein 4Q9UDX3Details
Hypoxanthine-guanine phosphoribosyltransferaseP00492Details
Retinoic acid receptor RXR-betaP28702Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialO95299Details
Ferritin light chainP02792Details
Histidine ammonia-lyaseP42357Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Q02809Details
Pyruvate kinase PKMP14618Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5O43920Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialO75380Details
Methylsterol monooxygenase 1Q15800Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialP11177Details
Alanine--glyoxylate aminotransferase 2, mitochondrialQ9BYV1Details
Ketimine reductase mu-crystallinQ14894Details
Carcinoembryonic antigen-related cell adhesion molecule 1P13688Details
Adenine phosphoribosyltransferaseP07741Details
Phospholipid-transporting ATPase ABCA1O95477Details
3-hydroxyisobutyrate dehydrogenase, mitochondrialP31937Details
Hemoglobin subunit alphaP69905Details
Androgen receptorP10275Details
Aldehyde dehydrogenase, mitochondrialP05091Details
Alpha-aminoadipic semialdehyde dehydrogenaseP49419Details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialP19404Details
Mitochondrial inner membrane m-AAA protease component AFG3L2Q9Y4W6Details
Tubulin beta chainP07437Details
NAD-dependent malic enzyme, mitochondrialP23368Details
Succinate-semialdehyde dehydrogenase, mitochondrialP51649Details
Sigma non-opioid intracellular receptor 1Q99720Details
Biotin--protein ligaseP50747Details
NADH-cytochrome b5 reductase 3P00387Details
D-3-phosphoglycerate dehydrogenaseO43175Details
2-oxoglutarate dehydrogenase complex component E1Q02218Details
L-serine dehydratase/L-threonine deaminaseP20132Details
Glutamate--cysteine ligase catalytic subunitP48506Details
Cytochrome c oxidase subunit NDUFA4O00483Details
Mitochondrial peptide methionine sulfoxide reductaseQ9UJ68Details
D-beta-hydroxybutyrate dehydrogenase, mitochondrialQ02338Details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialP31040Details
Carnitine O-palmitoyltransferase 2, mitochondrialP23786Details
Glutamate dehydrogenase 1, mitochondrialP00367Details
Pyridoxine-5'-phosphate oxidaseQ9NVS9Details
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7P56937Details
Glutathione synthetaseP48637Details
Bifunctional glutamate/proline--tRNA ligaseP07814Details
Scavenger receptor class B member 1Q8WTV0Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialO75489Details
Mitochondrial ornithine transporter 1Q9Y619Details
Retinoic acid receptor betaP10826Details
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicP21695Details
PlasminogenP00747Details
Ribosyldihydronicotinamide dehydrogenase [quinone]P16083Details
Valine--tRNA ligaseP26640Details
Alcohol dehydrogenase 1AP07327Details
Tyrosine--tRNA ligase, cytoplasmicP54577Details
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrialQ02252Details
Microsomal triglyceride transfer protein large subunitP55157Details
Adrenodoxin, mitochondrialP10109Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialO43674Details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialP30038Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10O96000Details
Purine nucleoside phosphorylaseP00491Details
4-aminobutyrate aminotransferase, mitochondrialP80404Details
5'-AMP-activated protein kinase subunit beta-1Q9Y478Details
SEC14-like protein 2O76054Details
Beta-1,4-galactosyltransferase 1P15291Details
Trifunctional enzyme subunit alpha, mitochondrialP40939Details
Nitric oxide synthase 3P29474Details
Gamma-glutamyl hydrolaseQ92820Details
NeprilysinP08473Details
Carbonic anhydrase 1P00915Details
Thialysine N-epsilon-acetyltransferaseQ96F10Details
Solute carrier family 12 member 7Q9Y666Details
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrialQ9UJS0Details
Antithrombin-IIIP01008Details
Sodium-coupled neutral amino acid transporter 3Q99624Details
Arginase-1P05089Details
4-trimethylaminobutyraldehyde dehydrogenaseP49189Details
HCG20471, isoform CRA_cQ5T1J1Details
Serine hydroxymethyltransferase, mitochondrialP34897Details
Alanine--tRNA ligase, cytoplasmicP49588Details
Sorbitol dehydrogenaseQ00796Details
Retinol-binding protein 1P09455Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialQ16795Details
Ornithine transcarbamylase, mitochondrialP00480Details
Retinol-binding protein 4P02753Details
Alanine--glyoxylate aminotransferaseP21549Details
3-hydroxyacyl-CoA dehydrogenase type-2Q99714Details
Methylmalonic aciduria type A protein, mitochondrialQ8IVH4Details
Carbonic anhydrase 2P00918Details
Cystathionine beta-synthaseP35520Details
11-beta-hydroxysteroid dehydrogenase 1P28845Details
Serine hydroxymethyltransferase, cytosolicP34896Details
TransthyretinP02766Details
Glycine amidinotransferase, mitochondrialP50440Details
Acetyl-coenzyme A synthetase, cytoplasmicQ9NR19Details
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrialQ96I99Details
GDH/6PGL endoplasmic bifunctional proteinO95479Details
All-trans-retinol dehydrogenase [NAD(+)] ADH4P08319Details
Coagulation factor IXP00740Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8P51970Details
Glycine N-methyltransferaseQ14749Details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialQ16836Details
Guided entry of tail-anchored proteins factor CAMLGP49069Details
Vitamin K-dependent protein CP04070Details
Dihydroorotate dehydrogenase (quinone), mitochondrialQ02127Details
Aspartate aminotransferase, mitochondrialP00505Details
KynureninaseQ16719Details
Isovaleryl-CoA dehydrogenase, mitochondrialP26440Details
Ferritin heavy chainP02794Details
All-trans-retinol dehydrogenase [NAD(+)] ADH1BP00325Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7O95182Details
Vitamin K-dependent gamma-carboxylaseP38435Details
S-adenosylmethionine synthase isoform type-1Q00266Details
Peroxisomal multifunctional enzyme type 2P51659Details
Retinoic acid receptor RXR-alphaP19793Details
Annexin A1P04083Details
Ornithine aminotransferase, mitochondrialP04181Details
L-lactate dehydrogenase A chainP00338Details
RAC-alpha serine/threonine-protein kinaseP31749Details
Methionine-R-sulfoxide reductase B2, mitochondrialQ9Y3D2Details
Serine/threonine-protein kinase A-RafP10398Details
Tyrosine-protein kinase ABL2P42684Details
Aldo-keto reductase family 1 member C4P17516Details
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialQ96RQ3Details
4-hydroxyphenylpyruvate dioxygenaseP32754Details
Corrinoid adenosyltransferase MMABQ96EY8Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1P22413Details
Alcohol dehydrogenase 1CP00326Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Q16718Details
Aldehyde dehydrogenase X, mitochondrialP30837Details
Aminoacylase-1Q03154Details
Threonine synthase-like 1Q8IYQ7Details
ATP synthase subunit delta, mitochondrialP30049Details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialP49821Details
Isoleucine--tRNA ligase, cytoplasmicP41252Details
Propionyl-CoA carboxylase alpha chain, mitochondrialP05165Details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialP28331Details
Carnitine O-acetyltransferaseP43155Details
Low-density lipoprotein receptorP01130Details
SerotransferrinP02787Details
Receptor tyrosine-protein kinase erbB-2P04626Details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialO75600Details
Argininosuccinate lyaseP04424Details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]Q15274Details
Glucagon receptorP47871Details
Aspartyl/asparaginyl beta-hydroxylaseQ12797Details
Aspartate aminotransferase, cytoplasmicP17174Details
AlbuminP02768Details
Chromodomain-helicase-DNA-binding protein 1O14646Details
Fibrinogen alpha chainP02671Details
Dihydropteridine reductaseP09417Details
Glyceraldehyde-3-phosphate dehydrogenaseP04406Details
Methionine--tRNA ligase, cytoplasmicP56192Details
Propionyl-CoA carboxylase beta chain, mitochondrialP05166Details
Acyl carrier protein, mitochondrialO14561Details
Sterol 26-hydroxylase, mitochondrialQ02318Details
Aldehyde dehydrogenase 1A1P00352Details
Cationic amino acid transporter 2P52569Details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialP08559Details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialP45954Details
3-hydroxy-3-methylglutaryl-coenzyme A reductaseP04035Details
(3R)-3-hydroxyacyl-CoA dehydrogenaseQ92506Details
Mitochondrial carnitine/acylcarnitine carrier proteinO43772Details
Peroxisomal bifunctional enzymeQ08426Details
Heme oxygenase 2P30519Details
Malate dehydrogenase, cytoplasmicP40925Details
Integrin alpha-4P13612Details
Aldo-keto reductase family 1 member C3P42330Details
Retinol dehydrogenase 13Q8NBN7Details
Flavin reductase (NADPH)P30043Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Q9Y6M9Details
Aldehyde dehydrogenase family 3 member A2P51648Details
Solute carrier family 12 member 4Q9UP95Details
Asparagine--tRNA ligase, cytoplasmicO43776Details
Putative hydrolase DDAH2O95865Details
Choline-phosphate cytidylyltransferase AP49585Details
C-1-tetrahydrofolate synthase, cytoplasmicP11586Details
Glycine dehydrogenase (decarboxylating), mitochondrialP23378Details
Acetyl-CoA carboxylase 1Q13085Details
Hemoglobin subunit betaP68871Details
Serine/threonine-protein kinase B-rafP15056Details
Choline dehydrogenase, mitochondrialQ8NE62Details
UMP-CMP kinaseP30085Details
Long-chain-fatty-acid--CoA ligase 1P33121Details
Alpha-tocopherol transfer proteinP49638Details
UDP-glucose 6-dehydrogenaseO60701Details
Glutathione reductase, mitochondrialP00390Details
GDP-L-fucose synthaseQ13630Details
Alanine aminotransferase 1P24298Details
Monocarboxylate transporter 1P53985Details
Argininosuccinate synthaseP00966Details
5'-AMP-activated protein kinase catalytic subunit alpha-1Q13131Details
Retinol-binding protein 5P82980Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3O95167Details
Tyrosine aminotransferaseP17735Details
Pyruvate carboxylase, mitochondrialP11498Details
Cysteine--tRNA ligase, cytoplasmicP49589Details
Acetyl-CoA carboxylase 2O00763Details
Bile salt export pumpO95342Details
ADP/ATP translocase 2P05141Details
Inosine-5'-monophosphate dehydrogenase 2P12268Details
Aspartate--tRNA ligase, cytoplasmicP14868Details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialQ8N5Z0Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialO75306Details
Sodium/potassium-transporting ATPase subunit alpha-1P05023Details
Dihydrolipoyl dehydrogenase, mitochondrialP09622Details
Histidine--tRNA ligase, cytoplasmicP12081Details
Biliverdin reductase AP53004Details
Fibroblast growth factor receptor 2P21802Details
ATPase GET3O43681Details
Sodium/hydrogen exchanger 1P19634Details
Phenylalanine-4-hydroxylaseP00439Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Q9UI09Details
Thromboxane A2 receptorP21731Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialP16219Details
Methionine synthase reductaseQ9UBK8Details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1O94760Details
Epidermal growth factor receptorP00533Details
Leucine--tRNA ligase, cytoplasmicQ9P2J5Details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialP51553Details
5'-AMP-activated protein kinase subunit beta-2O43741Details
Farnesyl pyrophosphate synthaseP14324Details
Methylmalonyl-CoA mutase, mitochondrialP22033Details
Malate dehydrogenase, mitochondrialP40926Details
Nicotinamide N-methyltransferaseP40261Details
Multidrug resistance-associated protein 1P33527Details
Cystathionine gamma-lyaseP32929Details
Glucocorticoid receptorP04150Details
Glutathione S-transferase kappa 1Q9Y2Q3Details
Glutathione S-transferase PP09211Details
Glutathione S-transferase omega-1P78417Details
Glutathione peroxidase 1P07203Details
Formimidoyltransferase-cyclodeaminaseO95954Details
Delta-1-pyrroline-5-carboxylate synthaseP54886Details
Glutaminase kidney isoform, mitochondrialO94925Details
Proto-oncogene tyrosine-protein kinase SrcP12931Details
Betaine--homocysteine S-methyltransferase 1Q93088Details
Macrophage colony-stimulating factor 1 receptorP07333Details
Dipeptidyl peptidase 4P27487Details
Perilipin-3O60664Details
L-xylulose reductaseQ7Z4W1Details
Dual specificity mitogen-activated protein kinase kinase 1Q02750Details
Protein kinase C beta typeP05771Details
Lanosterol 14-alpha demethylaseQ16850Details
Lysosomal alpha-glucosidaseP10253Details
Trifunctional purine biosynthetic protein adenosine-3P22102Details
Sulfotransferase 2A1Q06520Details
DNA (cytosine-5)-methyltransferase 1P26358Details
Cartilage oligomeric matrix proteinP49747Details
CalpastatinP20810Details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]P35558Details
Peroxiredoxin-5, mitochondrialP30044Details
Sepiapterin reductaseP35270Details
Alpha-2-macroglobulinP01023Details
Hepatocyte growth factor receptorP08581Details
Apolipoprotein A-IIP02652Details
Mitogen-activated protein kinase 1P28482Details
Sulfotransferase 1A1P50225Details
Serum paraoxonase/arylesterase 1P27169Details
Protein AMBPP02760Details
Cytosolic 10-formyltetrahydrofolate dehydrogenaseO75891Details
Phosphatidylcholine transfer proteinQ9UKL6Details
Cathepsin BP07858Details
Cathepsin DP07339Details
Vitamin K-dependent protein SP07225Details
Platelet basic proteinP02775Details
Bifunctional epoxide hydrolase 2P34913Details
Alpha-1-antitrypsinP01009Details
Cyclic AMP-responsive element-binding protein 1P16220Details
Fatty acid synthaseP49327Details
Dihydropyrimidine dehydrogenase [NADP(+)]Q12882Details
Lactoylglutathione lyaseQ04760Details
Thiamine transporter 2Q9BZV2Details
Apoptosis-inducing factor 1, mitochondrialO95831Details
DNA topoisomerase 1P11387Details
Beta-glucuronidaseP08236Details
Insulin receptor substrate 1P35568Details
Catenin beta-1P35222Details
Thiopurine S-methyltransferaseP51580Details
17-beta-hydroxysteroid dehydrogenase type 6O14756Details
Parkinson disease protein 7Q99497Details
LactotransferrinP02788Details
Glycine--tRNA ligaseP41250Details
Solute carrier organic anion transporter family member 1B1Q9Y6L6Details
Cytochrome b-c1 complex subunit 1, mitochondrialP31930Details
Cytochrome cP99999Details
CalnexinP27824Details
Peptidyl-prolyl cis-trans isomerase AP62937Details
Rho-associated protein kinase 1Q13464Details
Kininogen-1P01042Details
Mitogen-activated protein kinase 14Q16539Details
G1/S-specific cyclin-D1P24385Details
Basement membrane-specific heparan sulfate proteoglycan core proteinP98160Details
Ferrochelatase, mitochondrialP22830Details
Protein-glutamine gamma-glutamyltransferase 2P21980Details
Solute carrier organic anion transporter family member 2B1O94956Details
Solute carrier family 2, facilitated glucose transporter member 2P11168Details
Solute carrier family 2, facilitated glucose transporter member 1P11166Details
Choline transporter-like protein 1Q8WWI5Details
AngiotensinogenP01019Details
ATP-binding cassette sub-family C member 3O15438Details
Glycogen synthase kinase-3 betaP49841Details
VitronectinP04004Details
ATP-binding cassette sub-family C member 2Q92887Details
SomatostatinP61278Details
Tyrosine-protein phosphatase non-receptor type 11Q06124Details
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1P16118Details
Aminopeptidase NP15144Details
Intercellular adhesion molecule 1P05362Details
Nuclear factor NF-kappa-B p105 subunitP19838Details
5'-nucleotidaseP21589Details
Endoplasmic reticulum chaperone BiPP11021Details
Microtubule-associated protein 2P11137Details
CD44 antigenP16070Details
Apolipoprotein EP02649Details
Heat shock protein HSP 90-alphaP07900Details
Protein kinase C alpha typeP17252Details
Phospholipid hydroperoxide glutathione peroxidase GPX4P36969Details
CeruloplasminP00450Details
Vitamin D-binding proteinP02774Details
Protein-L-isoaspartate(D-aspartate) O-methyltransferaseP22061Details
Methylated-DNA--protein-cysteine methyltransferaseP16455Details
Beta-hexosaminidase subunit betaP07686Details
Inhibitor of nuclear factor kappa-B kinase subunit betaO14920Details
EndoplasminP14625Details
Microtubule-associated protein 1AP78559Details
Annexin A2P07355Details
RAC-beta serine/threonine-protein kinaseP31751Details
Cytochrome b5P00167Details
14-3-3 protein zeta/deltaP63104Details
ProsaposinP07602Details
Phosphatidylethanolamine-binding protein 1P30086Details
FibronectinP02751Details
Quinone oxidoreductaseQ08257Details
3-phosphoinositide-dependent protein kinase 1O15530Details
Fatty acid-binding protein, adipocyteP15090Details
Glucose-6-phosphate isomeraseP06744Details
Fibroblast growth factor receptor 4P22455Details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialP33316Details
Protein S100-A12P80511Details
CatalaseP04040Details
Serum amyloid P-componentP02743Details
m7GpppX diphosphataseQ96C86Details
Thymidylate kinaseP23919Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BQ13370Details
Bifunctional purine biosynthesis protein ATICP31939Details
Isocitrate dehydrogenase [NADP] cytoplasmicO75874Details
Adenylate kinase isoenzyme 1P00568Details
Pleckstrin homology domain-containing family A member 4Q9H4M7Details
Apolipoprotein(a)P08519Details
Non-secretory ribonucleaseP10153Details
Acetyl-CoA acetyltransferase, cytosolicQ9BWD1Details
MAP kinase-activated protein kinase 2P49137Details
Protein kinase C theta typeQ04759Details
Tubulin alpha-1C chainQ9BQE3Details
Tubulin alpha-4A chainP68366Details
Tyrosine-protein kinase HCKP08631Details
UDP-N-acetylhexosamine pyrophosphorylaseQ16222Details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitP36873Details
Lanosterol synthaseP48449Details
Adenosine 5'-monophosphoramidase HINT1P49773Details
UDP-glucose 4-epimeraseQ14376Details
Complement C1s subcomponentP09871Details
Methionine aminopeptidase 2P50579Details
DNA repair protein XRCC4Q13426Details
Coatomer subunit gamma-1Q9Y678Details
Cathepsin SP25774Details
Sialic acid-binding Ig-like lectin 7Q9Y286Details
2-iminobutanoate/2-iminopropanoate deaminaseP52758Details
Leukotriene A-4 hydrolaseP09960Details
Fructose-bisphosphate aldolase AP04075Details
AdenosylhomocysteinaseP23526Details
Ras-related protein Rab-9AP51151Details
Poly [ADP-ribose] polymerase 1P09874Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialP11310Details
Enoyl-CoA delta isomerase 1, mitochondrialP42126Details
Death-associated protein kinase 1P53355Details
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1Q9HAN9Details
Early endosome antigen 1Q15075Details
Hydroxyacylglutathione hydrolase, mitochondrialQ16775Details
Macrophage migration inhibitory factorP14174Details
TGF-beta receptor type-2P37173Details
Galectin-10Q05315Details
Thromboxane-A synthaseP24557Details
Heat shock protein HSP 90-betaP08238Details
Cyclin-dependent kinase 7P50613Details
Glutaryl-CoA dehydrogenase, mitochondrialQ92947Details
Peroxiredoxin-2P32119Details
Catechol O-methyltransferaseP21964Details
Fibrinogen beta chainP02675Details
Fibrinogen gamma chainP02679Details
Complement C1r subcomponentP00736Details
Laminin subunit alpha-5O15230Details
TetranectinP05452Details
Keratin, type II cytoskeletal 8P05787Details
Laminin subunit beta-1P07942Details
Laminin subunit gamma-1P11047Details
CalreticulinP27797Details
Prolow-density lipoprotein receptor-related protein 1Q07954Details
Nidogen-1P14543Details
Syndecan-2P34741Details
Phytanoyl-CoA dioxygenase, peroxisomalO14832Details
Asialoglycoprotein receptor 2P07307Details
Protein ERGIC-53P49257Details
Multiple coagulation factor deficiency protein 2Q8NI22Details
Retinoblastoma-associated proteinP06400Details
Synaptotagmin-like protein 4Q96C24Details
Serine protease hepsinP05981Details
Neuropilin-1O14786Details
Collagen alpha-1(III) chainP02461Details
Procathepsin LP07711Details
Collagen alpha-2(I) chainP08123Details
Serpin B6P35237Details
Pyridoxal phosphate homeostasis proteinO94903Details
Glycogen phosphorylase, brain formP11216Details
Aromatic-L-amino-acid decarboxylaseP20711Details
Pyridoxal-dependent decarboxylase domain-containing protein 1Q6P996Details
5-phosphohydroxy-L-lysine phospho-lyaseQ8IUZ5Details
Molybdenum cofactor sulfuraseQ96EN8Details
Serine dehydratase-likeQ96GA7Details
O-phosphoseryl-tRNA(Sec) selenium transferaseQ9HD40Details
Cyanocobalamin reductase / alkylcobalamin dealkylaseQ9Y4U1Details
CholinesteraseP06276Details
Phospholipase D1Q13393Details
Glutathione S-transferase A2P09210Details
Thymidine phosphorylaseP19971Details
Fatty-acid amide hydrolase 1O00519Details
Amine oxidase [flavin-containing] BP27338Details
Amine oxidase [flavin-containing] AP21397Details
Xanthine dehydrogenase/oxidaseP47989Details
Cyclin-dependent kinase 9P50750Details
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetaseP22234Details
Multifunctional protein CADP27708Details
Adenylosuccinate synthetase isozyme 2P30520Details
Aspartate--tRNA ligase, mitochondrialQ6PI48Details
Adenylosuccinate synthetase isozyme 1Q8N142Details
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)Q96HD9Details
Phosphoribosylformylglycinamidine synthaseO15067Details
Glutamine synthetaseP15104Details
Glutamine--tRNA ligaseP47897Details
S-methylmethionine--homocysteine S-methyltransferase BHMT2Q9H2M3Details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialO14521Details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialP21912Details
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialP53597Details
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialQ9P2R7Details
N-acetyl-D-glucosamine kinaseQ9UJ70Details
5-oxoprolinaseO14841Details
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrialQ5JPH6Details
Mitochondrial glutamate carrier 2Q9H1K4Details
Mitochondrial glutamate carrier 1Q9H936Details
Aspartyl aminopeptidaseQ9ULA0Details
Glutathione S-transferase 3, mitochondrialO14880Details
Thioredoxin domain-containing protein 12O95881Details
Glutathione S-transferase A1P08263Details
Microsomal glutathione S-transferase 1P10620Details
S-formylglutathione hydrolaseP10768Details
Glutaredoxin-1P35754Details
Microsomal glutathione S-transferase 2Q99735Details
Phosphatidylserine synthase 2Q9BVG9Details
Sphingomyelin phosphodiesterase 3Q9NY59Details
Glycine cleavage system H protein, mitochondrialP23434Details
Bile acid-CoA:amino acid N-acyltransferaseQ14032Details
Glycine N-acyltransferaseQ6IB77Details
Glycine N-acyltransferase-like protein 1Q969I3Details
Peroxisomal sarcosine oxidaseQ9P0Z9Details
Alanine--tRNA ligase, mitochondrialQ5JTZ9Details
Short-chain dehydrogenase/reductase 3O75911Details
Retinol dehydrogenase 11Q8TC12Details
Isoleucine--tRNA ligase, mitochondrialQ9NSE4Details
Peptidyl-prolyl cis-trans isomerase BP23284Details
Peptidyl-prolyl cis-trans isomerase GQ13427Details
Probable proline--tRNA ligase, mitochondrialQ7L3T8Details
Asparaginyl-tRNA synthetaseQ96I59Details
Proteasome subunit beta type-5P28074Details
Guanylate kinaseQ16774Details
Cytochrome P450 3A5P20815Details
NADPH--cytochrome P450 reductaseP16435Details
Histone deacetylase 1Q13547Details
Histone deacetylase 2Q92769Details
Histone deacetylase 6Q9UBN7Details
DNA-dependent protein kinase catalytic subunitP78527Details
Serine/threonine-protein kinase mTORP42345Details
Nuclear factor NF-kappa-B p100 subunitQ00653Details
Superoxide dismutase [Cu-Zn]P00441Details
NF-kappa-B essential modulatorQ9Y6K9Details
FurinP09958Details
Small ribosomal subunit protein uS2P08865Details
Disintegrin and metalloproteinase domain-containing protein 10O14672Details
Nicotinamide phosphoribosyltransferaseP43490Details
DNA repair nuclease/redox regulator APEX1P27695Details
Protein kinase C delta typeQ05655Details
DNA topoisomerase 2-betaQ02880Details
Fructose-1,6-bisphosphatase 1P09467Details
Cytochrome P450 1A2P05177Details
Histamine N-methyltransferaseP50135Details
Squalene synthaseP37268Details
Ephrin type-B receptor 4P54760Details
Plasma protease C1 inhibitorP05155Details
Keratin, type II cytoskeletal 7P08729Details
E3 ubiquitin-protein ligase UBR4Q5T4S7Details
NAD-dependent protein deacetylase sirtuin-1Q96EB6Details
Protein disulfide-isomeraseP07237Details
Non-selective voltage-gated ion channel VDAC1P21796Details
Voltage-dependent anion-selective channel protein 2P45880Details
N-terminal kinase-like proteinQ96KG9Details
Prostaglandin E synthase 3Q15185Details
Actin nucleation-promoting factor WASP42768Details
Histone-lysine N-methyltransferase SETD7Q8WTS6Details
C-terminal-binding protein 1Q13363Details
Cytochrome P450 3A4P08684Details
Peripheral plasma membrane protein CASKO14936Details
GephyrinQ9NQX3Details
Liver carboxylesterase 1P23141Details
U1 small nuclear ribonucleoprotein AP09012Details
ATP-dependent Clp protease proteolytic subunit, mitochondrialQ16740Details
Protein S100-A11P31949Details
Peroxisomal trans-2-enoyl-CoA reductaseQ9BY49Details
Cytochrome P450 2C9P11712Details
Immunoglobulin heavy constant gamma 1P01857Details
Copper transport protein ATOX1O00244Details
Estradiol 17-beta-dehydrogenase 11Q8NBQ5Details
Beta-2-glycoprotein 1P02749Details
Zinc-alpha-2-glycoproteinP25311Details
Cytochrome P450 2C8P10632Details
Sulfite oxidase, mitochondrialP51687Details
Protein S100-A6P06703Details
Nucleoside diphosphate kinase AP15531Details
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrialQ16698Details
Hepatocyte nuclear factor 4-gammaQ14541Details
Trafficking protein particle complex subunit 3O43617Details
Complement component C8 gamma chainP07360Details
ADP-ribosylation factor 4P18085Details
Nucleoside diphosphate kinase BP22392Details
GalactokinaseP51570Details
Axin-1O15169Details
Hydroxymethylglutaryl-CoA lyase, mitochondrialP35914Details
Cytochrome P450 2A6P11509Details
Calpain-1 catalytic subunitP07384Details
NAD-dependent protein deacylase sirtuin-5, mitochondrialQ9NXA8Details
Scavenger receptor cysteine-rich type 1 protein M130Q86VB7Details
Leptin receptorP48357Details
Cytochrome c oxidase subunit 2P00403Details
Thioredoxin reductase 2, mitochondrialQ9NNW7Details
Amyloid-beta precursor proteinP05067Details
Puromycin-sensitive aminopeptidaseP55786Details
Bcl-2-like protein 2Q92843Details
Bcl2-associated agonist of cell deathQ92934Details
cAMP-dependent protein kinase type II-alpha regulatory subunitP13861Details
cAMP-dependent protein kinase type I-alpha regulatory subunitP10644Details
High mobility group protein B1P09429Details
Heat shock protein beta-1P04792Details
Apolipoprotein A-IP02647Details
Complement C3P01024Details
T-cell surface glycoprotein CD3 zeta chainP20963Details
Signal transducer and activator of transcription 3P40763Details
Ribosome-binding protein 1Q9P2E9Details
Microtubule-associated protein 4P27816Details
Pro-neuropeptide YP01303Details
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2P16615Details
HLA class I histocompatibility antigen, A-3 alpha chainP04439Details
Alpha-mannosidase 2Q16706Details
Transmembrane anterior posterior transformation protein 1 homologQ6NXT6Details
Parathyroid hormone/parathyroid hormone-related peptide receptorQ03431Details
Casein kinase I isoform epsilonP49674Details
Heat shock factor protein 1Q00613Details
Monocyte differentiation antigen CD14P08571Details
Histone deacetylase 4P56524Details
Histone deacetylase 5Q9UQL6Details
Histone deacetylase 7Q8WUI4Details
Polyamine deacetylase HDAC10Q969S8Details
Cytochrome P450 2E1P05181Details
Cytochrome P450 2C19P33261Details
UDP-glucuronosyltransferase 1A9O60656Details
Aldehyde oxidaseQ06278Details
Adenosine kinaseP55263Details
UDP-glucuronosyltransferase 1A1P22309Details
Cytochrome P450 1A1P04798Details
UDP-glucuronosyltransferase 1A4P22310Details
Alcohol dehydrogenase 6P28332Details
Cytochrome P450 2B6P20813Details
6-phosphogluconate dehydrogenase, decarboxylatingP52209Details
Prostaglandin reductase 2Q8N8N7Details
Serum paraoxonase/lactonase 3Q15166Details
V-type proton ATPase catalytic subunit AP38606Details
Integrin beta-1P05556Details
Flavin-containing monooxygenase 3P31513Details
Aldo-keto reductase family 1 member D1P51857Details
DNA polymerase epsilon subunit 4Q9NR33Details
Cation-independent mannose-6-phosphate receptorP11717Details
Carbonic anhydrase 3P07451Details
Carbonic anhydrase 5A, mitochondrialP35218Details
Carbonic anhydrase 14Q9ULX7Details
Solute carrier family 22 member 1O15245Details
Monocarboxylate transporter 10Q8TF71Details
Solute carrier organic anion transporter family member 1B3Q9NPD5Details
Copper-transporting ATPase 1Q04656Details
UDP-glucuronosyltransferase 2B7P16662Details
UDP-glucuronosyltransferase 2B17O75795Details
UDP-glucuronosyltransferase 2B4P06133Details
Cytochrome P450 2J2P51589Details
Matrix metalloproteinase-15P51511Details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortP63092Details
Nuclear receptor coactivator 2Q15596Details
Nuclear receptor-interacting protein 1P48552Details
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformP30153Details
Disintegrin and metalloproteinase domain-containing protein 17P78536Details
cAMP-dependent protein kinase catalytic subunit alphaP17612Details
2-Hydroxyacid oxidase 1Q9UJM8Details
S-phase kinase-associated protein 1P63208Details
Heat shock cognate 71 kDa proteinP11142Details
Beta-2-microglobulinP61769Details
Glycylpeptide N-tetradecanoyltransferase 2O60551Details
Low molecular weight phosphotyrosine protein phosphataseP24666Details
Calcium/calmodulin-dependent protein kinase type II subunit betaQ13554Details
Prostaglandin reductase 1Q14914Details
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformP63151Details
Malonyl-CoA-acyl carrier protein transacylase, mitochondrialQ8IVS2Details
ADP-ribosylation factor 1P84077Details
Large ribosomal subunit protein uL14P62829Details
Large ribosomal subunit protein eL19P84098Details
Large ribosomal subunit protein uL23P62750Details
Large ribosomal subunit protein uL2P62917Details
Large ribosomal subunit protein uL3P39023Details
Large ribosomal subunit protein uL5P62913Details
NHP2-like protein 1P55769Details
ATP synthase subunit alpha, mitochondrialP25705Details
ATP synthase subunit beta, mitochondrialP06576Details
ATP synthase subunit gamma, mitochondrialP36542Details
Triosephosphate isomeraseP60174Details
Cytochrome c1, heme protein, mitochondrialP08574Details
Cytochrome b-c1 complex subunit 2, mitochondrialP22695Details
Cytochrome b-c1 complex subunit 7P14927Details
Cytochrome b-c1 complex subunit 9Q9UDW1Details
Cytosol aminopeptidaseP28838Details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialQ16134Details
Protein kinase C iota typeP41743Details
Myosin-14Q7Z406Details
Proteasome subunit alpha type-1P25786Details
Proteasome subunit alpha type-2P25787Details
Proteasome subunit alpha type-3P25788Details
Proteasome subunit alpha type-4P25789Details
Proteasome subunit alpha type-5P28066Details
Proteasome subunit alpha type-6P60900Details
Proteasome subunit alpha type-7O14818Details
Proteasome subunit beta type-3P49720Details
Proteasome subunit beta type-4P28070Details
Proteasome subunit beta type-7Q99436Details
Retinoid-inducible serine carboxypeptidaseQ9HB40Details
Pro-cathepsin HP09668Details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrialP13073Details
Cytochrome c oxidase subunit 5A, mitochondrialP20674Details
Cytochrome c oxidase subunit 5B, mitochondrialP10606Details
Cytochrome c oxidase subunit 6B1P14854Details
Fatty acid-binding protein, liverP07148Details
Dual specificity tyrosine-phosphorylation-regulated kinase 1AQ13627Details
Hepatocyte nuclear factor 4-alphaP41235Details
STE20-like serine/threonine-protein kinaseQ9H2G2Details
Calcium/calmodulin-dependent protein kinase type IVQ16566Details
Dual specificity protein kinase CLK3P49761Details
Isopentenyl-diphosphate Delta-isomerase 1Q13907Details
Nuclear receptor coactivator 5Q9HCD5Details
Hydroxymethylglutaryl-CoA synthase, cytoplasmicQ01581Details
HLA class I histocompatibility antigen, B-27 alpha chainP01889Details
Calcium/calmodulin-dependent protein kinase type II subunit deltaQ13557Details
Serine/threonine-protein kinase 26Q9P289Details
Methionine aminopeptidase 1P53582Details
Profilin-1P07737Details
Peroxisomal acyl-coenzyme A oxidase 1Q15067Details
D-amino-acid oxidaseP14920Details
Calpain small subunit 1P04632Details
Tyrosine-protein kinase JAK1P23458Details
Annexin A5P08758Details
Myocardin-related transcription factor AQ969V6Details
GelsolinP06396Details
Cofilin-1P23528Details
Rho-associated protein kinase 2O75116Details
Enoyl-CoA delta isomerase 2O75521Details
ADP-ribosylation factor 6P62330Details
Actin-related protein 2/3 complex subunit 1BO15143Details
Actin-related protein 2P61160Details
Actin-related protein 3P61158Details
Actin-related protein 2/3 complex subunit 2O15144Details
Actin-related protein 2/3 complex subunit 3O15145Details
Actin-related protein 2/3 complex subunit 5O15511Details
Ribosomal protein S6 kinase alpha-1Q15418Details
Elongation factor 2P13639Details
Myosin regulatory light chain 12AP19105Details
Tyrosine-protein kinase LynP07948Details
SRSF protein kinase 2P78362Details
Calcium/calmodulin-dependent protein kinase type 1DQ8IU85Details
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialQ6NVY1Details
Glycylpeptide N-tetradecanoyltransferase 1P30419Details
AfadinP55196Details
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrialQ15119Details
Protein S100-A4P26447Details
Aldo-keto reductase family 1 member A1P14550Details
CREB-binding proteinQ92793Details
Iodotyrosine deiodinase 1Q6PHW0Details
Acyl-coenzyme A thioesterase 13Q9NPJ3Details
Mediator of RNA polymerase II transcription subunit 1Q15648Details
Calcium/calmodulin-dependent protein kinase type II subunit gammaQ13555Details
RNA-splicing ligase RtcB homologQ9Y3I0Details
Epsin-1Q9Y6I3Details
Superoxide dismutase [Mn], mitochondrialP04179Details
Phosphoglycerate kinase 1P00558Details
Thiosulfate sulfurtransferaseQ16762Details
Citrate synthase, mitochondrialO75390Details
Beta-enolaseP13929Details
Phosphoglucomutase-1P36871Details
VimentinP08670Details
Uridine 5'-monophosphate synthaseP11172Details
Cytochrome b5 type BO43169Details
cAMP-dependent protein kinase catalytic subunit betaP22694Details
Acyl-CoA-binding proteinP07108Details
Adenylate kinase 2, mitochondrialP54819Details
NADPH:adrenodoxin oxidoreductase, mitochondrialP22570Details
Mannose-binding protein CP11226Details
Ras-related protein Rab-7aP51149Details
Myosin-11P35749Details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1P51178Details
Galectin-1P09382Details
Cation-dependent mannose-6-phosphate receptorP20645Details
Enoyl-CoA hydratase, mitochondrialP30084Details
Signal recognition particle 14 kDa proteinP37108Details
Aconitate hydratase, mitochondrialQ99798Details
Vesicle-fusing ATPaseP46459Details
DecorinP07585Details
Hepatocyte nuclear factor 1-alphaP20823Details
Poly(A) polymerase alphaP51003Details
RadixinP35241Details
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseP26572Details
6-pyruvoyl tetrahydrobiopterin synthaseQ03393Details
3-ketoacyl-CoA thiolase, peroxisomalP09110Details
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1Q14643Details
V-type proton ATPase subunit C 1P21283Details
Isocitrate dehydrogenase [NADP], mitochondrialP48735Details
FumarylacetoacetaseP16930Details
Palmitoyl-protein thioesterase 1P50897Details
Elongation factor Tu, mitochondrialP49411Details
NAD-dependent protein deacetylase sirtuin-3, mitochondrialQ9NTG7Details
Gamma-enolaseP09104Details
T-complex protein 1 subunit gammaP49368Details
Pterin-4-alpha-carbinolamine dehydrataseP61457Details
GTP-binding nuclear protein RanP62826Details
N-acylneuraminate cytidylyltransferaseQ8NFW8Details
Fructose-bisphosphate aldolase BP05062Details
Carboxypeptidase DO75976Details
Acylphosphatase-2P14621Details
14-3-3 protein epsilonP62258Details
Branched-chain alpha-ketoacid dehydrogenase kinaseO14874Details
Transitional endoplasmic reticulum ATPaseP55072Details
Ubiquitin-like modifier-activating enzyme 1P22314Details
2-Hydroxyacid oxidase 2Q9NYQ3Details
Sorting nexin-3O60493Details
FAD-linked sulfhydryl oxidase ALRP55789Details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5O60264Details
Catechol O-methyltransferase domain-containing protein 1Q86VU5Details
Spectrin beta chain, non-erythrocytic 1Q01082Details
Spliceosome RNA helicase DDX39BQ13838Details
Selenocysteine lyaseQ96I15Details
Versican core proteinP13611Details
Ribosomal protein S6 kinase alpha-4O75676Details
Hepatocyte growth factor-regulated tyrosine kinase substrateO14964Details
Acireductone dioxygenaseQ9BV57Details
Serine/threonine-protein kinase TAO2Q9UL54Details
Small COPII coat GTPase SAR1BQ9Y6B6Details
ADP-ribosylation factor-like protein 3P36405Details
Peroxiredoxin-6P30041Details
Carbamoyl-phosphate synthase [ammonia], mitochondrialP31327Details
Coagulation factor XIIP00748Details
Electrogenic sodium bicarbonate cotransporter 1Q9Y6R1Details
UDP-glucuronosyltransferase 1-6P19224Details
UDP-glucuronosyltransferase 2B15P54855Details
Neutral alpha-glucosidase ABQ14697Details
Deoxycytidylate deaminaseP32321Details
Sodium/nucleoside cotransporter 1O00337Details
Cocaine esteraseO00748Details
Cytochrome P450 4F2P78329Details
Proteasome subunit beta type-10P40306Details
Proteasome subunit beta type-8P28062Details
Tyrosine-protein kinase FRKP42685Details
Breakpoint cluster region proteinP11274Details
Dual specificity mitogen-activated protein kinase kinase 2P36507Details
Mitogen-activated protein kinase kinase kinase 2Q9Y2U5Details
Anoctamin-1Q5XXA6Details
ATP-binding cassette sub-family G member 8Q9H221Details
RalA-binding protein 1Q15311Details
Ethanolamine-phosphate cytidylyltransferaseQ99447Details
Metallothionein-2P02795Details
Adenylate kinase 4, mitochondrialP27144Details
Solute carrier family 2, facilitated glucose transporter member 9Q9NRM0Details
Serum amyloid A-1 proteinP0DJI8Details
Transferrin receptor protein 1P02786Details
Transferrin receptor protein 2Q9UP52Details
Serine-protein kinase ATMQ13315Details
Ribosomal protein S6 kinase alpha-3P51812Details
Protein kinase C zeta typeQ05513Details
Membrane-associated progesterone receptor component 1O00264Details
Sodium channel protein type 7 subunit alphaQ01118Details
Cytochrome b-245 heavy chainP04839Details
5'-AMP-activated protein kinase subunit gamma-1P54619Details
5'-AMP-activated protein kinase subunit gamma-2Q9UGJ0Details
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2Q14571Details
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3Q14573Details
Cyclic AMP-dependent transcription factor ATF-2P15336Details
Cyclic AMP-dependent transcription factor ATF-7P17544Details
Complement component 1 Q subcomponent-binding protein, mitochondrialQ07021Details
Intracellular hyaluronan-binding protein 4Q5JVS0Details
Stabilin-2Q8WWQ8Details
ThioredoxinP10599Details
Sodium/potassium-transporting ATPase subunit beta-1P05026Details
Arsenite methyltransferaseQ9HBK9Details
Apolipoprotein DP05090Details
Immunoglobulin heavy constant alpha 1P01876Details
Immunoglobulin heavy constant muP01871Details
Histone H1.4P10412Details
Cytoplasmic aconitate hydrataseP21399Details
RegucalcinQ15493Details
Chloride intracellular channel protein 1O00299Details
Casein kinase II subunit betaP67870Details
C-type lectin domain family 14 member AQ86T13Details
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENP60484Details
Selenoprotein PP49908Details
Mitogen-activated protein kinase kinase kinase 20Q9NYL2Details
Dihydropyrimidinase-related protein 2Q16555Details
Alpha-enolaseP06733Details
Protein PMLP29590Details
Copper chaperone for superoxide dismutaseO14618Details
Endonuclease 8-like 2Q969S2Details
Nucleolar and coiled-body phosphoprotein 1Q14978Details
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Q15750Details
Apoptosis regulatory protein SivaO15304Details
UtrophinP46939Details
Peroxiredoxin-1Q06830Details
Apolipoprotein B receptorQ0VD83Details
Apolipoprotein C-IIP02655Details
Apolipoprotein C-IIIP02656Details
Hydroxyacid-oxoacid transhydrogenase, mitochondrialQ8IWW8Details
Tricarboxylate transport protein, mitochondrialP53007Details
Sodium-dependent phosphate transporter 2Q08357Details
Cytochrome c oxidase copper chaperoneQ14061Details
SorcinP30626Details
Calcineurin B homologous protein 1Q99653Details
Translationally-controlled tumor proteinP13693Details
Nucleobindin-1Q02818Details
Nucleobindin-2P80303Details
Calmodulin-2P0DP24Details
Calmodulin-3P0DP25Details
Calreticulin-3Q96L12Details
Protein S100-A8P05109Details
60 kDa heat shock protein, mitochondrialP10809Details
Small ribosomal subunit protein uS5P15880Details
Heterogeneous nuclear ribonucleoproteins A2/B1P22626Details
Heterogeneous nuclear ribonucleoprotein HP31943Details
Heterogeneous nuclear ribonucleoprotein H3P31942Details
Heterogeneous nuclear ribonucleoprotein LP14866Details
Splicing factor, proline- and glutamine-richP23246Details
Small ribosomal subunit protein RACK1P63244Details
Alpha-actinin-1P12814Details
Annexin A4P09525Details
Stress-induced-phosphoprotein 1P31948Details
Eukaryotic translation initiation factor 6P56537Details
Eukaryotic initiation factor 4A-IP60842Details
14-3-3 protein beta/alphaP31946Details
Hepatoma-derived growth factorP51858Details
Proteasome activator complex subunit 1Q06323Details
Phosphoglycerate mutase 1P18669Details
Ran-specific GTPase-activating proteinP43487Details
Protein disulfide-isomerase A3P30101Details
Serpin B9P50453Details
Phosphatidylinositol 4-kinase type 2-betaQ8TCG2Details
Integrin alpha-5P08648Details
Cystatin-BP04080Details
Protein S100-A9P06702Details
HuntingtinP42858Details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Q8N1G2Details
Macrophage receptor MARCOQ9UEW3Details
Minor histocompatibility antigen H13Q8TCT9Details
Prohibitin-2Q99623Details
Flap endonuclease 1P39748Details
Eukaryotic translation initiation factor 3 subunit FO00303Details
RuvB-like 2Q9Y230Details
Splicing factor 3B subunit 3Q15393Details
ATP synthase subunit e, mitochondrialP56385Details
ATP synthase subunit g, mitochondrialO75964Details
Diablo IAP-binding mitochondrial proteinQ9NR28Details
Heterogeneous nuclear ribonucleoprotein FP52597Details
Heterogeneous nuclear ribonucleoprotein KP61978Details
Heat shock 70 kDa protein 4P34932Details
10 kDa heat shock protein, mitochondrialP61604Details
Heat shock protein 105 kDaQ92598Details
Nuclear migration protein nudCQ9Y266Details
26S proteasome regulatory subunit 6AP17980Details
Protein S100-A10P60903Details
Splicing factor 3A subunit 3Q12874Details
Tumor protein D54O43399Details
Tropomyosin alpha-1 chainP09493Details
Tropomyosin alpha-3 chainP06753Details
Tropomyosin alpha-4 chainP67936Details
Ubiquitin carboxyl-terminal hydrolase 14P54578Details
14-3-3 protein etaQ04917Details
14-3-3 protein thetaP27348Details
Proliferating cell nuclear antigenP12004Details
Alpha-1B-glycoproteinP04217Details
Alpha-2-HS-glycoproteinP02765Details
Apolipoprotein A-IVP06727Details
C4b-binding protein alpha chainP04003Details
Complement component C8 beta chainP07358Details
Complement component C9P02748Details
Complement factor HP08603Details
Complement factor IP05156Details
ClusterinP10909Details
Chromobox protein homolog 5P45973Details
Inter-alpha-trypsin inhibitor heavy chain H2P19823Details
Keratin, type II cytoskeletal 1P04264Details
Keratin, type I cytoskeletal 10P13645Details
Keratin, type II cytoskeletal 2 epidermalP35908Details
Keratin, type I cytoskeletal 9P35527Details
Leucine-rich alpha-2-glycoproteinP02750Details
LumicanP51884Details
Apolipoprotein L1O14791Details
Complement component C8 alpha chainP07357Details
DermcidinP81605Details
DesmoplakinP15924Details
HornerinQ86YZ3Details
Inter-alpha-trypsin inhibitor heavy chain H1P19827Details
Inter-alpha-trypsin inhibitor heavy chain H4Q14624Details
Junction plakoglobinP14923Details
Keratin, type I cytoskeletal 14P02533Details
Keratin, type I cytoskeletal 16P08779Details
Keratin, type II cytoskeletal 5P13647Details
Keratin, type II cytoskeletal 6AP02538Details
Far upstream element-binding protein 2Q92945Details
ATP synthase subunit O, mitochondrialP48047Details
Cysteine and glycine-rich protein 1P21291Details
Filamin-AP21333Details
Heterogeneous nuclear ribonucleoprotein D0Q14103Details
Heterochromatin protein 1-binding protein 3Q5SSJ5Details
Ras GTPase-activating-like protein IQGAP1P46940Details
NucleophosminP06748Details
Large ribosomal subunit protein uL16P27635Details
Large ribosomal subunit protein eL18Q07020Details
Large ribosomal subunit protein uL29P42766Details
Large ribosomal subunit protein uL4P36578Details
Small ribosomal subunit protein uS15P62277Details
Small ribosomal subunit protein eS17P08708Details
Small ribosomal subunit protein uS13P62269Details
Small ribosomal subunit protein eS28P62857Details
Small ribosomal subunit protein uS7P46782Details
Small ribosomal subunit protein eS6P62753Details
Small ribosomal subunit protein eS8P62241Details
Small ribosomal subunit protein uS4P46781Details
Splicing factor 1Q15637Details
Serine/arginine-rich splicing factor 4Q08170Details
Transgelin-2P37802Details
ZyxinQ15942Details
Serine/arginine-rich splicing factor 1Q07955Details
Survival motor neuron proteinB4DP61Details
Transient receptor potential cation channel subfamily V member 2Q9Y5S1Details
TransgelinQ01995Details
Myosin-9P35579Details
Bone morphogenetic protein receptor type-2Q13873Details
Beta-ureidopropionaseQ9UBR1Details
Macrophage mannose receptor 1P22897Details
Nuclear receptor subfamily 1 group D member 1P20393Details
Splicing factor 3B subunit 1O75533Details
Serine/threonine-protein kinase TAO1Q7L7X3Details
Serine/threonine-protein kinase TAO3Q9H2K8Details
Serine/threonine-protein kinase tousled-like 2Q86UE8Details
TRAF2 and NCK-interacting protein kinaseQ9UKE5Details
Non-receptor tyrosine-protein kinase TNK1Q13470Details
AP2-associated protein kinase 1Q2M2I8Details
BMP-2-inducible protein kinaseQ9NSY1Details
Calcium/calmodulin-dependent protein kinase type 1Q14012Details
Calcium/calmodulin-dependent protein kinase kinase 1Q8N5S9Details
Calcium/calmodulin-dependent protein kinase kinase 2Q96RR4Details
Interferon-induced, double-stranded RNA-activated protein kinaseP19525Details
Tyrosine-protein kinase Fes/FpsP07332Details
Cyclin-G-associated kinaseO14976Details
Glycogen synthase kinase-3 alphaP49840Details
Homeodomain-interacting protein kinase 2Q9H2X6Details
Serine/threonine-protein kinase SIK3Q9Y2K2Details
Serine/threonine-protein kinase LATS1O95835Details
Leucine-rich repeat serine/threonine-protein kinase 2Q5S007Details
Mitogen-activated protein kinase kinase kinase 11Q16584Details
Mitogen-activated protein kinase kinase kinase kinase 2Q12851Details
Mitogen-activated protein kinase kinase kinase kinase 4O95819Details
Mitogen-activated protein kinase kinase kinase kinase 5Q9Y4K4Details
CLIP-associating protein 1Q7Z460Details
Misshapen-like kinase 1Q8N4C8Details
Myosin light chain kinase, smooth muscleQ15746Details
Serine/threonine-protein kinase Nek1Q96PY6Details
Serine/threonine-protein kinase Nek3P51956Details
Serine/threonine-protein kinase Nek9Q8TD19Details
Serine/threonine-protein kinase OSR1O95747Details
Serine/threonine-protein kinase PAK 1Q13153Details
Serine/threonine-protein kinase PAK 2Q13177Details
Serine/threonine-protein kinase PAK 4O96013Details
Phosphatidylinositol 4-kinase betaQ9UBF8Details
Serine/threonine-protein kinase N1Q16512Details
Serine/threonine-protein kinase N2Q16513Details
cGMP-dependent protein kinase 2Q13237Details
Serine/threonine-protein kinase PRP4 homologQ13523Details
Receptor-interacting serine/threonine-protein kinase 1Q13546Details
Receptor-interacting serine/threonine-protein kinase 2O43353Details
Serine/threonine-protein kinase SIK2Q9H0K1Details
Serine/threonine-protein kinase 10O94804Details
Epoxide hydrolase 1P07099Details
Alpha-methylacyl-CoA racemaseD6RB81Details
Insulin-like growth factor-binding protein 1P08833Details
Insulin-like growth factor-binding protein 2P18065Details
Insulin-like growth factor-binding protein 4P22692Details
Inositol polyphosphate 1-phosphataseP49441Details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialQ16822Details
Exportin-1O14980Details
POU domain, class 2, transcription factor 1P14859Details
NAD-dependent protein deacetylase sirtuin-2Q8IXJ6Details
HLA class II histocompatibility antigen, DR alpha chainP01903Details
N-sulphoglucosamine sulphohydrolaseP51688Details
Prohibitin 1P35232Details
DystrophinP11532Details
Aflatoxin B1 aldehyde reductase member 3O95154Details
P2X purinoceptor 7Q99572Details
Histone-lysine N-methyltransferase EZH1Q92800Details
ATP-citrate synthaseP53396Details
Long-chain fatty acid transport protein 2O14975Details
Nucleoside diphosphate phosphatase ENTPD5O75356Details
Proton-coupled zinc antiporter SLC30A9, mitochondrialQ6PML9Details
Zinc transporter SLC39A7Q92504Details
Metal cation symporter ZIP14Q15043Details
Apolipoprotein B-100P04114Details
HemopexinP02790Details
Histidine-rich glycoproteinP04196Details
HaptoglobinP00738Details
Receptor tyrosine-protein kinase erbB-3P21860Details
Serum paraoxonase/arylesterase 2Q15165Details
Diacylglycerol kinase zetaQ13574Details
Tyrosine-protein phosphatase non-receptor type 12Q05209Details
V-type proton ATPase 116 kDa subunit a 1Q93050Details
V-type proton ATPase subunit E 1P36543Details
V-type proton ATPase subunit HQ9UI12Details
Mitochondrial potassium channelQ96ER9Details
Plasma membrane calcium-transporting ATPase 1P20020Details
Plasma membrane calcium-transporting ATPase 2Q01814Details
Plasma membrane calcium-transporting ATPase 4P23634Details
Beta-galactosidaseP16278Details
Interleukin-6 receptor subunit betaP40189Details
Sphingosine kinase 2Q9NRA0Details
Immunoglobulin heavy constant gamma 3P01860Details
Leucyl-cystinyl aminopeptidaseQ9UIQ6Details
Molybdopterin synthase catalytic subunitO96007Details
Receptor protein-tyrosine kinaseQ504U8Details
3-ketoacyl-CoA thiolase, mitochondrialP42765Details
Potassium-transporting ATPase alpha chain 2P54707Details
HLA class I histocompatibility antigen, C alpha chainP10321Details
Arylacetamide deacetylaseP22760Details
Eukaryotic translation initiation factor 4E-binding protein 1Q13541Details
Lysine-specific histone demethylase 1AO60341Details
Signal transducer and activator of transcription 1-alpha/betaP42224Details
Histone acetyltransferase p300Q09472Details
Dual specificity mitogen-activated protein kinase kinase 4P45985Details
cAMP-dependent protein kinase type I-beta regulatory subunitP31321Details
3-oxoacyl-[acyl-carrier-protein] reductaseQ8N4T8Details
CD276 antigenQ5ZPR3Details
Cytochrome P450 7B1O75881Details
Perilipin-1O60240Details
Adenylate cyclase type 6O43306Details
Adenylate cyclase type 9O60503Details
IgG receptor FcRn large subunit p51P55899Details
Asialoglycoprotein receptor 1P07306Details