Nucleotide triphosphate diphosphatase NUDT15

BE0009809ProteinHumansNUDT15

Catalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). It is acted on by 1 drug in DrugBank.

Gene name
NUDT15
UniProtKB entry
Q9NV35Swiss-Prot
Residues / weight
164 residues · 18,609 Da
Also known as
3.6.1.68 · 3.6.1.76 · 3.6.1.9 · MTH2 · MutT homolog 2

Resolves to

Protein
UniProtQ9NV35UniProt nameNUD15_HUMAN
Gene
HGNCHGNC:23063NCBI Gene55270GeneCardsNUDT15
Pharmacology
KEGGhsa:55270
Structure
PDB5BONPDB5LPGPDB6T5J
Drugs

What you can answer from here — as of January 13, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleotide triphosphate diphosphatase NUDT15, how selective are they, and which programs against it are still in active trials?

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