Guanylate cyclase soluble subunit beta-1

BE0010029ProteinHumansGUCY1B1

Beta subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It is acted on by 9 drugs in DrugBank.

Gene name
GUCY1B1
UniProtKB entry
Q02153Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
619 residues · 70,514 Da
Also known as
4.6.1.2 · GCS-beta-1 · GCS-beta-3 · Guanylate cyclase soluble subunit beta-3 · GUC1B3

Resolves to

Protein
UniProtQ02153UniProt nameGCYB1_HUMAN
Gene
HGNCHGNC:4687NCBI Gene2983GeneCardsGUCY1B1
Pharmacology
IUPHAR/GtoPdb1290KEGGhsa:2983
Structure
PDB2WZ1PDB3UVJPDB4NI2
Drugs

What you can answer from here — as of January 21, 2021

9DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanylate cyclase soluble subunit beta-1, how selective are they, and which programs against it are still in active trials?

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