Guanylate cyclase soluble subunit alpha-1

BE0010061ProteinHumansGUCY1A1

Alpha subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It is acted on by 7 drugs in DrugBank.

Gene name
GUCY1A1
UniProtKB entry
Q02108Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
690 residues · 77,452 Da
Also known as
4.6.1.2 · GCS-alpha-1 · GCS-alpha-3 · Guanylate cyclase soluble subunit alpha-3 · GUC1A3

Resolves to

Protein
UniProtQ02108UniProt nameGCYA1_HUMAN
Gene
HGNCHGNC:4685NCBI Gene2982GeneCardsGUCY1A1
Pharmacology
IUPHAR/GtoPdb1288KEGGhsa:2982
Structure
PDB3UVJPDB4NI2PDB6JT0
Drugs

What you can answer from here — as of May 07, 2021

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanylate cyclase soluble subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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