Interleukin-33

BE0010097ProteinHumansIL33

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). It is acted on by 5 drugs in DrugBank.

Gene name
IL33
UniProtKB entry
O95760Swiss-Prot
Cellular location
Nucleus
Residues / weight
270 residues · 30,759 Da
Also known as
C9orf26 · IL-1F11 · IL-33 · IL1F11 · Interleukin-1 family member 11

Resolves to

Protein
UniProtO95760UniProt nameIL33_HUMAN
Gene
HGNCHGNC:16028NCBI Gene90865GeneCardsIL33
Pharmacology
KEGGhsa:90865
Structure
PDB2KLLPDB4KC3PDB9WWH
Drugs

What you can answer from here — as of October 27, 2021

5DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interleukin-33, and which indications are they being tested in?

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