Heat shock 70 kDa protein 1A

BE0010433ProteinHumansHSPA1A

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation... It is acted on by 7 drugs in DrugBank.

Gene name
HSPA1A
UniProtKB entry
P0DMV8Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
641 residues · 70,052 Da
Also known as
Heat shock 70 kDa protein 1 · Heat shock protein family A member 1A · HSP70-1 · HSP70.1 · HSP72

Resolves to

Protein
UniProtP0DMV8UniProt nameHS71A_HUMAN
Gene
HGNCHGNC:5232NCBI Gene3304GeneCardsHSPA1A
Pharmacology
IUPHAR/GtoPdb2539KEGGhsa:3304
Structure
PDB1HJOPDB1S3XPDB1XQS
Drugs

What you can answer from here — as of October 31, 2023

7DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Heat shock 70 kDa protein 1A, and which indications are they being tested in?

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