Stimulator of interferon genes protein

BE0010703ProteinHumansSTING1

Key innate immune signaling adapter that promotes the production of type I interferon (IFN-alpha and IFN-beta) in response to the presence of DNA from bacteria and viruses in the cytosol (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953,... It is acted on by 8 drugs in DrugBank.

Gene name
STING1
UniProtKB entry
Q86WV6Swiss-Prot
Cellular location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Residues / weight
379 residues · 42,192 Da
Also known as
Endoplasmic reticulum interferon stimulator · ERIS · hMITA · hSTING · Mediator of IRF3 activation

Resolves to

Protein
UniProtQ86WV6UniProt nameSTING_HUMAN
Gene
HGNCHGNC:27962NCBI Gene340061GeneCardsSTING1
Pharmacology
IUPHAR/GtoPdb2902KEGGhsa:340061
Structure
PDB4EF4PDB4EF5PDB4EMT
Drugs

What you can answer from here — as of October 31, 2023

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Stimulator of interferon genes protein, and which indications are they being tested in?

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