ADU-S100

DB14722InvestigationalSmall molecule

ADU-S100 (MIW815) is a synthetic cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. ADU-S100 (MIW815) activates all... ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression of cytokines and chemokines, leading to a robust and durable antigen-specific T-cell mediated immune response against cancer cells.

Mechanism: Pharmacologically active on Stimulator of interferon genes protein
Curator reviewed
Formula / weight: C₂₀H₂₄N₁₀O₁₀P₂S₂ · 690.54 g/mol (avg)
Also known as: ADU-S100 free acid
Code names: ADU-S100 · MIW815 · NVP-MIW815

Resolves to

Compound

UNIINV32768L81CAS1638241-89-0

Structure

InChIKeyIZJJFUQKKZFVLH-YBVMPXGUSA-NSMILES

NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2CO[P@](S)(=O)O[C@@H]3[C@H](O)[C@@H](CO[P@](S)(=O)O[C@H]2[C@H]1O)O[C@H]3N1C=NC2=C1N=CN=C2N

Targets

Q86WV6STING1

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with ADU-S100, and which of those have an active Phase 3 trial?

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