Diacylglycerol O-acyltransferase 1

BE0012021ProteinHumansDGAT1

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). It is acted on by 5 drugs in DrugBank.

Gene name
DGAT1
UniProtKB entry
O75907Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
488 residues · 55,278 Da
Also known as
2.3.1.20 · ACAT-related gene product 1 · Acyl-CoA retinol O-fatty-acyltransferase · AGRP1 · ARAT

Resolves to

Protein
UniProtO75907UniProt nameDGAT1_HUMAN
Gene
HGNCHGNC:2843NCBI Gene8694GeneCardsDGAT1
Pharmacology
IUPHAR/GtoPdb2821KEGGhsa:8694
Structure
PDB6VP0PDB6VYIPDB6VZ1
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Diacylglycerol O-acyltransferase 1, and which indications are they being tested in?

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