Interleukin-12 subunit alpha

BE0012862ProteinHumansIL12A

Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). It is acted on by 5 drugs in DrugBank.

Gene name
IL12A
UniProtKB entry
P29459Swiss-Prot
Cellular location
Secreted
Residues / weight
219 residues · 24,874 Da
Also known as
CLMF p35 · Cytotoxic lymphocyte maturation factor 35 kDa subunit · IL-12 subunit p35 · IL-12A · NK cell stimulatory factor chain 1

Resolves to

Protein
UniProtP29459UniProt nameIL12A_HUMAN
Gene
HGNCHGNC:5969NCBI Gene3592GeneCardsIL12A
Pharmacology
KEGGhsa:3592
Structure
PDB1F45PDB3HMXPDB8XRP
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-12 subunit alpha, how selective are they, and which programs against it are still in active trials?

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