Interleukin-12 subunit alpha

Details

Name
Interleukin-12 subunit alpha
Kind
protein
Synonyms
  • CLMF p35
  • Cytotoxic lymphocyte maturation factor 35 kDa subunit
  • IL-12 subunit p35
  • IL-12A
  • NK cell stimulatory factor chain 1
  • NKSF1
Gene Name
IL12A
UniProtKB Entry
P29459Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0049311|Interleukin-12 subunit alpha
MCPARSLLLVATLVLLDHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLE
FYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMM
ALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQK
SSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS
Number of residues
219
Molecular Weight
24873.72
Theoretical pI
Not Available
GO Classification
Functions
cytokine activity / growth factor activity / interleukin-12 beta subunit binding / interleukin-12 receptor binding / interleukin-27 binding / protein heterodimerization activity
Processes
cell migration / cellular response to virus / defense response to Gram-positive bacterium / extrinsic apoptotic signaling pathway / immune response / interleukin-12-mediated signaling pathway / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of interleukin-17 production / negative regulation of protein secretion / negative regulation of smooth muscle cell proliferation / negative regulation of vascular endothelial growth factor signaling pathway / positive regulation of cell adhesion / positive regulation of dendritic cell chemotaxis / positive regulation of lymphocyte proliferation / positive regulation of mononuclear cell proliferation / positive regulation of natural killer cell activation / positive regulation of natural killer cell mediated cytotoxicity / positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / positive regulation of NK T cell activation / positive regulation of smooth muscle cell apoptotic process / positive regulation of T cell mediated cytotoxicity / positive regulation of type II interferon production / positive regulation of tyrosine phosphorylation of STAT protein / response to lipopolysaccharide / response to UV-B / response to virus
Components
endoplasmic reticulum lumen / extracellular region / extracellular space / interleukin-12 complex / late endosome lumen
General Function
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:1673147, PubMed:1674604, PubMed:8605935). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits (PubMed:8943050). Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2 (PubMed:7528775). In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (PubMed:7638186). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers (PubMed:22306691). Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (PubMed:22306691)
Specific Function
cytokine activity
Pfam Domain Function
Signal Regions
1-22
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
Not Available
Chromosome Location
3
Locus
3q25.33
External Identifiers
ResourceLink
UniProtKB IDP29459
UniProtKB Entry NameIL12A_HUMAN
GeneCard IDIL12A
HGNC IDHGNC:5969
PDB ID(s)1F45, 3HMX
KEGG IDhsa:3592
NCBI Gene ID3592
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
ApilimodinvestigationalyestargetinhibitorDetails