Potassium channel subfamily K member 10

BE0013513ProteinHumansKCNK10

K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. It is acted on by 8 drugs in DrugBank.

Gene name
KCNK10
UniProtKB entry
P57789Swiss-Prot
Cellular location
Cell membrane
Residues / weight
538 residues · 59,764 Da
Also known as
Outward rectifying potassium channel protein TREK-2 · TREK-2 K(+) channel subunit · TREK2

Resolves to

Protein
UniProtP57789UniProt nameKCNKA_HUMAN
Gene
HGNCHGNC:6273NCBI Gene54207GeneCardsKCNK10
Pharmacology
IUPHAR/GtoPdb521KEGGhsa:54207
Structure
PDB4BW5PDB4XDJPDB4XDK
Drugs

What you can answer from here — as of September 03, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium channel subfamily K member 10, how selective are they, and which programs against it are still in active trials?

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