Serine Protease Inhibitors

Serine Protease Inhibitors
Accession Number

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.

DrugDrug Description
LepirudinA protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia.
BivalirudinA direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.
Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
ChymostatinNot Available
BenzamidineA drug used to treat painful and inflammatory conditions of the oral cavity, such as infections and gingivitis.
XimelagatranFor the treatment of acute deep vein thrombosis.
RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
IdraparinuxInvestigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation.
ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
OtamixabanInvestigated for use/treatment in thrombosis.
AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
Dabigatran etexilateAn anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.
EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
LetaxabanLetaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.
UlinastatinUlinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug.
DarexabanDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
NafamostatUsed as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement...
GabexateA protease inhibitor indicated in the treatment of acute pancreatitis.
SivelestatSivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.
MelagatranNot Annotated
CamostatA serine protease indicated in Japan to treat chronic pancreatitis.
Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
DabigatranDabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate.
FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
Human C1-esterase inhibitorA C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
DesirudinIndicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
BetrixabanA Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.
CGS-27023Not Available
GW-813893Not Available
BerotralstatAn inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema.
AlirocumabA PCSK9 inhibitor used as an adjunct to manage heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-cholesterol (LDL-C).
EvolocumabA PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures.
Conestat alfaA recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults.
Rosmarinic acidNot Annotated
Recombinant Alpha-1-antitrypsinNot Annotated
CTB001CTB001 is an anti-claudin 18.2 autologous chimeric antigen receptor (CAR) T-cell therapy under investigation for the treatment of gastric cancers.
Drugs & Drug Targets
Alpha-1-proteinase inhibitorNeutrophil elastasetarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
ChymostatinPeptide amidasetarget
BenzamidineUrokinase-type plasminogen activatortarget
BenzamidineCasein kinase II subunit alphatarget
BenzamidineCopper transport protein ATOX1target
BenzamidineEnoyl-CoA delta isomerase 1, mitochondrialtarget
BenzamidineSuppressor of tumorigenicity 14 proteintarget
XimelagatranCytochrome P450 2C9enzyme
RivaroxabanCoagulation factor Xtarget
RivaroxabanCytochrome P450 3A4enzyme
RivaroxabanCytochrome P450 2J2enzyme
RivaroxabanP-glycoprotein 1transporter
RivaroxabanCytochrome P450 3A5enzyme
RivaroxabanATP-binding cassette sub-family G member 2transporter
IdraparinuxCoagulation factor Xtarget
ApixabanCoagulation factor Xtarget
ApixabanCytochrome P450 3A4enzyme
ApixabanCytochrome P450 1A2enzyme
ApixabanCytochrome P450 2C8enzyme
ApixabanCytochrome P450 2C9enzyme
ApixabanCytochrome P450 2C19enzyme
ApixabanCytochrome P450 2J2enzyme
ApixabanP-glycoprotein 1transporter
ApixabanATP-binding cassette sub-family G member 2transporter
ApixabanCytochrome P450 3A5enzyme
OtamixabanCoagulation factor Xtarget
AprotininChymotrypsinogen Btarget
Dabigatran etexilateProthrombintarget
Dabigatran etexilateP-glycoprotein 1transporter
Dabigatran etexilateLiver carboxylesterase 1enzyme
Dabigatran etexilateCocaine esteraseenzyme
Dabigatran etexilateUDP-glucuronosyltransferase 1-9enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B7enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B15enzyme
Dabigatran etexilateRibosyldihydronicotinamide dehydrogenase [quinone]enzyme
Dabigatran etexilateSerum albumincarrier
EdoxabanCoagulation factor Xtarget
EdoxabanP-glycoprotein 1transporter
NafamostatIntercellular adhesion molecule 1target
NafamostatCoagulation factor Xtarget
NafamostatCoagulation factor XIItarget
NafamostatSolute carrier family 22 member 1transporter
NafamostatSolute carrier family 22 member 2transporter
GabexateComplement C1s subcomponentenzyme
GabexateComplement C1r subcomponentenzyme
GabexatePlasma kallikreintarget
CamostatTransmembrane protease serine 2target
CamostatSuppressor of tumorigenicity 14 proteintarget
Cholesterol sulfateNuclear receptor ROR-alphatarget
FondaparinuxCoagulation factor Xtarget
Human C1-esterase inhibitorComplement C1r subcomponenttarget
Human C1-esterase inhibitorComplement C1s subcomponenttarget
Human C1-esterase inhibitorPlasma kallikreintarget
Human C1-esterase inhibitorCoagulation factor XIItarget
Human C1-esterase inhibitorProthrombintarget
Human C1-esterase inhibitorCoagulation factor XItarget
Human C1-esterase inhibitorTissue-type plasminogen activatortarget
DesirudinCarboxypeptidase A1enzyme
BetrixabanP-glycoprotein 1transporter
BetrixabanCoagulation factor Xtarget
BetrixabanPotassium voltage-gated channel subfamily H member 2transporter
CGS-27023Macrophage metalloelastasetarget
CGS-27023Interstitial collagenasetarget
GW-813893Coagulation factor Xtarget
BerotralstatCytochrome P450 2D6enzyme
BerotralstatCytochrome P450 3A4enzyme
BerotralstatP-glycoprotein 1transporter
BerotralstatATP-binding cassette sub-family G member 2transporter
BerotralstatPlasma kallikreintarget
AlirocumabProprotein convertase subtilisin/kexin type 9target
EvolocumabProprotein convertase subtilisin/kexin type 9target
Conestat alfaComplement C1r subcomponenttarget
Conestat alfaComplement C1s subcomponenttarget
Conestat alfaPlasma kallikreintarget
Conestat alfaCoagulation factor XIItarget
Conestat alfaProthrombintarget
Conestat alfaCoagulation factor XItarget
Conestat alfaTissue-type plasminogen activatortarget