Name
Insulin
Accession Number
DBCAT000170  (DBCAT000136)
Description

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Drugs
DrugDrug Description
Insulin lisproA modified form of fast-acting insulin used to control hyperglycemia in diabetes mellitus.
Insulin glargineA modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus.
Insulin aspartA rapid-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin detemirA long-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin glulisineA short-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus.
Insulin degludecA long acting insulin used to treat hyperglycemia caused by type 1 and 2 diabetes mellitus.
Insulin porkA purified form of porcine insulin used to control hyperglycemia in diabetes mellitus.
NN344Investigated for use/treatment in diabetes mellitus type 1 and 2.
Insulin peglisproNot Annotated
Insulin humanA recombinant form of human insulin used to control hyperglycemia in diabetes mellitus.
Insulin beefInsulin beef has been discontinued in the US and Canada since 2017.
Insulin tregopilcode text here
Insulin argineNot Annotated
C-peptideC-peptide is under investigation in clinical trial NCT00278980 (Effect of C-peptide on Diabetic Peripheral Neuropathy).
Pegylated synthetic human c-peptideNot Annotated
Drugs & Drug Targets
DrugTargetType
Insulin lisproInsulin receptortarget
Insulin lisproInsulin-like growth factor 1 receptortarget
Insulin lisproCytochrome P450 1A2enzyme
Insulin lisproInsulin-degrading enzymeenzyme
Insulin glargineInsulin receptortarget
Insulin glargineInsulin-like growth factor 1 receptortarget
Insulin glargineCytochrome P450 1A2enzyme
Insulin aspartInsulin receptortarget
Insulin aspartInsulin-like growth factor 1 receptortarget
Insulin aspartCytochrome P450 1A2enzyme
Insulin detemirInsulin receptortarget
Insulin detemirSerum albumincarrier
Insulin detemirInsulin-like growth factor 1 receptortarget
Insulin detemirCytochrome P450 1A2enzyme
Insulin glulisineInsulin receptortarget
Insulin glulisineInsulin-like growth factor 1 receptortarget
Insulin glulisineCytochrome P450 1A2enzyme
Insulin degludecInsulin receptortarget
Insulin degludecInsulin-like growth factor 1 receptortarget
Insulin degludecSerum albumincarrier
Insulin degludecCytochrome P450 1A2enzyme
Insulin porkInsulin receptortarget
Insulin porkInsulin-like growth factor 1 receptortarget
Insulin porkCytochrome P450 1A2enzyme
Insulin porkInsulin-degrading enzymeenzyme
NN344Insulin receptortarget
NN344Cytochrome P450 1A2enzyme
Insulin peglisproCytochrome P450 1A2enzyme
Insulin peglisproInsulin receptortarget
Insulin peglisproInsulin-like growth factor 1 receptortarget
Insulin humanInsulin receptortarget
Insulin humanInsulin-like growth factor 1 receptortarget
Insulin humanInsulin-degrading enzymeenzyme
Insulin humanNeuroendocrine convertase 2enzyme
Insulin humanNeuroendocrine convertase 1enzyme
Insulin humanCytochrome P450 1A2enzyme
Insulin humanCarboxypeptidase Etarget
Insulin humanProtein NOV homologtarget
Insulin humanLow-density lipoprotein receptor-related protein 2target
Insulin humanInsulin-like growth factor-binding protein 7target
Insulin beefCytochrome P450 1A2enzyme
Insulin beefInsulin-like growth factor 1 receptortarget
Insulin beefInsulin receptortarget
Insulin beefInsulin-degrading enzymeenzyme
Insulin tregopilCytochrome P450 1A2enzyme
Insulin tregopilInsulin-like growth factor 1 receptortarget
Insulin tregopilInsulin receptortarget
Insulin argineCytochrome P450 1A2enzyme
Insulin argineInsulin-like growth factor 1 receptortarget
Insulin argineInsulin receptortarget