Amino Acids, Basic

Name
Amino Acids, Basic
Accession Number
DBCAT000280
Description

Amino acids with side chains that are positively charged at physiological pH.

Drugs
DrugDrug Description
L-LysineAn amino acid commonly found as a component of total parenteral nutrition.
ArginineAn amino acid commonly found as a component of total parenteral nutrition.
L-GlutamineAn amino acid commonly found as a component in total parenteral nutrition.
AsparagineUsed for nutritional supplementation, also for treating dietary shortage or imbalance.
N,N-dimethylarginineAsymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells which...
N-(Phosphonoacetyl)-L-OrnithineNot Available
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineNot Available
RWJ-51084Not Available
AceglutamideNot Available
N(2)-(2-carboxyethyl)-L-arginineNot Available
NitroarginineAn inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in...
beta-HydroxyasparagineNot Available
DansyllysineNot Available
PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
TalotrexinInvestigated for use/treatment in solid tumors, lung cancer, leukemia (unspecified), and leukemia (lymphoid).
EflornithineA medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin.
ClonixinIndicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
TilarginineTilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.
AstodrimerAstodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.
N-omega-nitro-L-arginine methyl esterL-NAME has been investigated for the treatment of Hypotension and Spinal Cord Injury.
ProglumideNot Annotated
OrnithineAn amino acid commonly found as a component in total parenteral nutrition.
CiraparantagCiraparantag is under investigation in clinical trial NCT01826266 (Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban).
L-homoarginineNot Available
N-acetyl-L-arginineNot Available
N(G)-IminoethylornithineNot Available
Epsilon-N-methyllysineNot Available
Symmetric dimethylarginineNot Available
IsoglutamineNot Available
TrimethyllysineNot Available
L-SaccharopineNot Available
FasitibantFasitibant is under investigation in clinical trial NCT02205814 (Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee).
KetoprofenAn NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain.
Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
Drugs & Drug Targets
DrugTargetType
L-LysineHigh affinity cationic amino acid transporter 1target
L-LysineCationic amino acid transporter 4target
L-LysineCationic amino acid transporter 3target
L-LysineLow affinity cationic amino acid transporter 2target
L-LysineLysine--tRNA ligasetarget
L-LysineMonocarboxylate transporter 10transporter
L-LysineSolute carrier family 22 member 4transporter
ArginineCationic amino acid transporter 3target
ArginineArginine decarboxylasetarget
ArginineArgininosuccinate lyasetarget
ArginineNitric oxide synthase, inducibletarget
ArginineHigh affinity cationic amino acid transporter 1target
ArginineArginase-2, mitochondrialtarget
ArginineCationic amino acid transporter 4target
ArginineArgininosuccinate synthasetarget
ArginineNitric oxide synthase, endothelialtarget
ArginineSolute carrier family 22 member 5transporter
ArginineMonocarboxylate transporter 10transporter
ArginineSolute carrier family 22 member 4transporter
L-GlutamineCTP synthase 1target
L-GlutamineAmidophosphoribosyltransferasetarget
L-GlutamineGlutamine synthetasetarget
L-GlutamineMonocarboxylate transporter 10transporter
L-GlutamineCoagulation factor XIII A chainenzyme
L-GlutamineGlutaminase kidney isoform, mitochondrialenzyme
L-GlutamineGlutaminase liver isoform, mitochondrialenzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase 2enzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase 5enzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase 6enzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase Kenzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase 4enzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase Eenzyme
L-GlutamineProtein-glutamine gamma-glutamyltransferase Zenzyme
L-GlutamineSodium-coupled neutral amino acid transporter 3transporter
L-GlutamineNeutral amino acid transporter B(0)transporter
L-GlutamineGMP synthase [glutamine-hydrolyzing]enzyme
L-GlutamineAsparagine synthetase [glutamine-hydrolyzing]enzyme
L-GlutamineKynurenine--oxoglutarate transaminase 1enzyme
L-GlutaminePhosphoribosylformylglycinamidine synthaseenzyme
L-GlutamineGlutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrialenzyme
L-GlutamineGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 2enzyme
L-GlutamineCAD proteinenzyme
L-GlutamineGlutamine--tRNA ligaseenzyme
L-GlutamineGlutamine-dependent NAD(+) synthetaseenzyme
L-GlutamineLarge neutral amino acids transporter small subunit 2transporter
L-GlutamineSodium-coupled neutral amino acid transporter 1transporter
L-GlutamineSodium-coupled neutral amino acid transporter 2transporter
L-GlutamineSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
L-GlutamineY+L amino acid transporter 1transporter
L-GlutamineY+L amino acid transporter 2transporter
L-GlutamineLarge neutral amino acids transporter small subunit 1transporter
L-GlutamineB(0,+)-type amino acid transporter 1transporter
AsparagineNeutral amino acid transporter B(0)target
AsparagineAsparagine synthetase [glutamine-hydrolyzing]target
AsparagineAsparagine--tRNA ligase, cytoplasmictarget
AsparagineIsoaspartyl peptidase/L-asparaginasetarget
AsparagineProbable asparagine--tRNA ligase, mitochondrialtarget
AsparagineMonocarboxylate transporter 10transporter
AsparagineSodium-coupled neutral amino acid transporterstarget
N,N-dimethylarginineNitric oxide synthase, inducibletarget
N,N-dimethylarginineNitric oxide synthase, endothelialtarget
N-(Phosphonoacetyl)-L-OrnithineOrnithine carbamoyltransferase, mitochondrialtarget
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineNitric oxide synthase, endothelialtarget
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineNitric oxide synthase oxygenasetarget
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineNitric oxide synthase, inducibletarget
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineArginase-1target
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineNitric oxide synthase, braintarget
RWJ-51084Trypsin-1target
AceglutamideN-acylamino acid racemasetarget
NitroarginineNitric oxide synthase, endothelialtarget
NitroarginineNitric oxide synthase, braintarget
beta-HydroxyasparagineMannan-binding lectin serine protease 2target
DansyllysineIg alpha-2 chain C regiontarget
PalifosfamideDNA (cytosine-5)-methyltransferase 1target
EflornithineOrnithine decarboxylasetarget
AstodrimerEnvelope glycoprotein gp160target
OrnithineOrnithine aminotransferase, mitochondrialtarget
OrnithineOrnithine carbamoyltransferase, mitochondrialtarget
OrnithineArginase-1target
OrnithineOrnithine decarboxylase antizyme 1target
OrnithineLow affinity cationic amino acid transporter 2target
OrnithineMitochondrial ornithine transporter 2target
OrnithineHigh affinity cationic amino acid transporter 1target
OrnithineArginase-2, mitochondrialtarget
OrnithineMitochondrial ornithine transporter 1target
OrnithineGlycine amidinotransferase, mitochondrialtarget
L-homoarginineNitric oxide synthase, endothelialtarget
N-acetyl-L-arginineClavaminate synthase 1target
N(G)-IminoethylornithineNitric oxide synthase, endothelialtarget
Symmetric dimethylarginineHaloalkane dehalogenasetarget
IsoglutamineATP synthase subunit btarget
TrimethyllysineCytochrome ctarget
TrimethyllysineCalmodulintarget
L-SaccharopineAlpha-aminoadipic semialdehyde synthase, mitochondrialtarget
KetoprofenProstaglandin G/H synthase 1target
KetoprofenProstaglandin G/H synthase 2target
KetoprofenC-X-C chemokine receptor type 1target
KetoprofenSerum albumincarrier
KetoprofenMultidrug resistance-associated protein 4transporter
KetoprofenSolute carrier organic anion transporter family member 1A2transporter
KetoprofenSolute carrier family 22 member 6transporter
KetoprofenSolute carrier family 22 member 8transporter
KetoprofenSolute carrier family 22 member 11transporter
KetoprofenSolute carrier family 22 member 7transporter
KetoprofenCytochrome P450 2C9enzyme
KetoprofenCytochrome P450 2C8enzyme
KetoprofenUDP-glucuronosyltransferase 1-1enzyme
Acetylsalicylic acidProstaglandin G/H synthase 1target
Acetylsalicylic acidProstaglandin G/H synthase 2target
Acetylsalicylic acidAldo-keto reductase family 1 member C1target
Acetylsalicylic acidSolute carrier family 22 member 6transporter
Acetylsalicylic acidP-glycoprotein 1transporter
Acetylsalicylic acidCytochrome P450 2C19enzyme
Acetylsalicylic acidCytochrome P450 2C9enzyme
Acetylsalicylic acid5'-AMP-activated protein kinasetarget
Acetylsalicylic acidEndothelin-1 receptortarget
Acetylsalicylic acidCellular tumor antigen p53target
Acetylsalicylic acid78 kDa glucose-regulated proteintarget
Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
Acetylsalicylic acidCaspase-1target
Acetylsalicylic acidCaspase-3target
Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
Acetylsalicylic acidG1/S-specific cyclin-D1target
Acetylsalicylic acidMyc proto-oncogene proteintarget
Acetylsalicylic acidProliferating cell nuclear antigentarget
Acetylsalicylic acidCyclin Atarget
Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
Acetylsalicylic acidSolute carrier family 22 member 8transporter