Fatty Acids, Essential

Name
Fatty Acids, Essential
Accession Number
DBCAT000303
Description

Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.

Drugs
DrugDrug Description
alpha-Linolenic acidA polyunsaturated omega-3 fatty acid found in many supplements.
Arachidonic AcidA natural fatty acid that plays an essential role in physiological homeostases, such as repair and growth of cells.
Borage oilBorage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as...
Evening primrose oilEvening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical...
Gamolenic acidAn ingredient found in a variety of nutritional products.
Linoleic acidNot Annotated
Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
Leukotriene C4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates...
Leukotriene D4Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis.
Leukotriene B4Leukotriene B4 has been used in trials studying the treatment of HIV Infections.
EdasalonexentEdasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes).
alpha-Hydroxylinoleic acidalpha-Hydroxylinoleic acid is under investigation in clinical trial NCT04431258 (ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic Study).
ArachidonyltrifluoromethaneSpecific inhibitor of phospholipase A2.
Drugs & Drug Targets
DrugTargetType
alpha-Linolenic acidFatty acid-binding protein, braincarrier
alpha-Linolenic acidFatty acid desaturase 1target
alpha-Linolenic acidFatty acid desaturase 2target
alpha-Linolenic acidSodium/calcium exchanger 1target
alpha-Linolenic acidTransient receptor potential cation channel subfamily V member 1target
alpha-Linolenic acidPeroxisome proliferator-activated receptor alphatarget
alpha-Linolenic acidBile acid receptortarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor deltatarget
alpha-Linolenic acidPeroxisome proliferator-activated receptor gammatarget
alpha-Linolenic acidRetinoic acid receptor RXR-alphatarget
alpha-Linolenic acidElongation of very long chain fatty acids protein 2target
alpha-Linolenic acidElongation of very long chain fatty acids protein 5target
Arachidonic AcidProstaglandin G/H synthase 1target
Arachidonic AcidSerum albumincarrier
Arachidonic AcidFatty acid-binding protein, adipocytecarrier
Arachidonic Acid14 kDa fatty acid-binding proteintarget
Arachidonic AcidFatty acid-binding protein, intestinalcarrier
Arachidonic AcidCytochrome P450 2C9enzyme
Arachidonic AcidSolute carrier organic anion transporter family member 2A1transporter
Arachidonic AcidPeroxisome proliferator-activated receptor alphatarget
Arachidonic AcidBile acid receptortarget
Arachidonic AcidRetinoic acid receptor RXR-alphatarget
Evening primrose oilElongation of very long chain fatty acids protein 5enzyme
Evening primrose oilFatty acid desaturase 1enzyme
Evening primrose oilFatty acid desaturase 2enzyme
Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
Leukotriene C4Cysteinyl leukotriene receptor 1target
Leukotriene C4Cysteinyl leukotriene receptor 2target
Leukotriene C4Multidrug resistance-associated protein 1target
Leukotriene D4Cysteinyl leukotriene receptor 1target
Leukotriene D4Cysteinyl leukotriene receptor 2target
Leukotriene B4Leukotriene B4 receptor 1target
Leukotriene B4Leukotriene B4 receptor 2target
Leukotriene B4Peroxisome proliferator-activated receptor alphatarget