Appetite Depressants

Name
Appetite Depressants
Accession Number
DBCAT000473
Description

Agents that are used to suppress appetite.

Drugs
DrugDrug Description
PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
PhenylpropanolamineA sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy.
PhenmetrazineUsed as an anorectic in the treatment of obesity.
DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
SibutramineA norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity.
CathineUsed to decrease appetite.
NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
GaboxadolInvestigated for use/treatment in sleep disorders and insomnia.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
Drugs & Drug Targets
DrugTargetType
PhentermineSodium-dependent noradrenaline transportertarget
PhentermineSodium-dependent dopamine transportertarget
PhentermineAmine oxidase [flavin-containing] Atarget
PhentermineAmine oxidase [flavin-containing] Btarget
PhentermineSodium-dependent serotonin transportertarget
PhenterminePro-neuropeptide Ytarget
PhentermineCytochrome P450 3A4enzyme
PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
PhenylpropanolamineDopamine D1 receptortarget
PhenylpropanolamineBeta-1 adrenergic receptortarget
PhenylpropanolamineBeta-2 adrenergic receptortarget
PhenylpropanolamineAlpha-2 adrenergic receptorstarget
PhenmetrazineSodium-dependent noradrenaline transportertarget
PhenmetrazineSodium-dependent dopamine transportertarget
DiethylpropionSodium-dependent noradrenaline transportertarget
DiethylpropionSodium-dependent dopamine transportertarget
SibutramineSodium-dependent serotonin transportertarget
SibutramineSodium-dependent noradrenaline transportertarget
SibutramineCytochrome P450 3A4enzyme
SibutramineSodium-dependent dopamine transportertarget
NalmefeneMu-type opioid receptortarget
NalmefeneKappa-type opioid receptortarget
NalmefeneDelta-type opioid receptortarget
NalmefeneUDP-glucuronosyltransferase 2B7enzyme
NalmefeneUDP-glucuronosyltransferase 1-3enzyme
NalmefeneUDP-glucuronosyltransferase 1-8enzyme
GaboxadolProton-coupled amino acid transporter 1transporter