Diethylpropion is an appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction. A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category.
- Mechanism
- Curator reviewed
Diethylpropion is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Diethylpropion (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that diethylpropion can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
- Primary indication
- Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.Curator reviewed · 1 structured indication
- Formula / weight
- C13H19NO · 205.2961 g/mol (avg)
- First approval
- Canada, 2006 · United States, 1959
- Also known as
- alpha-Benzoyltriethylamine · alpha-Diethylaminopropiophenone · Amfepramone · Diethylcathinone
- Code names
- DEA No. 1610
- Brand names
Resolves to
XXEPPPIWZFICOJ-UHFFFAOYSA-NSMILESCCN(CC)C(C)C(=O)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Diethylpropion, and which of those have an active Phase 3 trial?
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