Acids, Carbocyclic
- Name
- Acids, Carbocyclic
- Accession Number
- DBCAT000583
- Description
Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.
- Drugs
Drug Drug Description Tranexamic acid An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Bacitracin A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Dicyclomine An antimuscarinic agent used to treat IBS. Proparacaine A topical anesthetic used for ophthalmic practice. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Cyclopentolate An anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Oxybutynin An antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void. Benzocaine A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Iohexol A contrast agent for intrathecal administration used in myelography and contrast enhancement for computerized tomography. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Benzoyl peroxide An antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea. Acalabrutinib A Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Capmatinib A kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping. Bentiromide Indicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Benzyl benzoate A topical treatment for scabies and lice. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Olsalazine An anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat plaque psoriasis. Benzene Hexacarboxylic Acid Not Available Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... 3-(5-amino-7-hydroxy-(1,2,3)triazolo(4,5-d)pyrimidin-2-yl)benzoic acid Not Available Gabaculine Not Available 4-guanidinobenzoic acid Not Available Pyromellitic Acid Not Available 2,4-Dihydroxybenzoic Acid Not Available Arotinoid acid Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist. 3-Methoxybenzamide Not Available 4-Fluorobenzylamine Not Available GW-3965 GW-3965 is a liver X receptor ligand. Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). 3,4-Dihydroxybenzoic Acid Not Available Balanol Not Available 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Not Available Acedoben Not Available Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Itopride An acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting. Tamibarotene Investigated for use/treatment in leukemia (unspecified). Apadenoson Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified). ADL5859 Investigated for use/treatment in pain (acute or chronic). INCB3284 Investigated for use/treatment in inflammatory disorders (unspecified). Atl146e Investigated for use/treatment in inflammatory disorders (unspecified). APD791 For the treatment and prophylaxis of arterial thrombosis. VX-765 Investigated for use/treatment in inflammatory disorders (unspecified) and psoriasis and psoriatic disorders. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. SB-743921 Investigated for use/treatment in cancer/tumors (unspecified) and lymphoma (non-hodgkin's). SLx-4090 Investigated for use/treatment in hyperlipidemia. SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Ispinesib Investigated for use/treatment in breast cancer, lung cancer, solid tumors, renal cell carcinoma, pediatric indications, ovarian cancer, and head and neck cancer. Solabegron Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence. Eltrombopag A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies. Dersalazine Investigated for use/treatment in inflammatory bowel disease. Onalespib Investigated for use/treatment in cancer/tumors (unspecified). Tucidinostat Investigated for use/treatment in cancer/tumors (unspecified). FK-960 Investigated for use/treatment in dementia, alzheimer's disease, schizophrenia and schizoaffective disorders, and memory loss. Aplaviroc Investigated for use/treatment in HIV infection. Tonabersat Investigated for use/treatment in migraine and cluster headaches. Saredutant Investigated for use/treatment in depression and anxiety disorders. Lixivaptan Investigated for use/treatment in hyponatremia and congestive heart failure. Phenyl aminosalicylate Not Annotated PD-0325901 PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others. PH-797804 PH-797804 has been investigated for the treatment of Osteoarthritis. Platensimycin Not Available Prephenic acid Not Available 4-(Dimethylamino)benzoic acid Not Available Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Enzalutamide An androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer. Etamivan Etamivan (INN) or ethamivan (USAN) is marketed under the name Analepticon. Etamvin is a respiratory stimulant drug similar to nikethamide. It is no longer used in the United States. Amylocaine A local and topical anaesthetic agent. Methyl salicylate A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons. Octisalate Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer. Homosalate As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. Phenyl salicylate Pain and fever . Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Butamben Anesthesia of mucus membranes other than the eyes. Padimate A Padimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to... Glycol salicylate A salicylate used to treat mild to moderate muscle pain. Lufenuron Lufenuron is used in veterinary for the control of flea. Butacaine Not Annotated Masitinib Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... Tricaine Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin... Padimate O An ingredient used in sunscreens to absorb UV radiation. Candoxatrilat A dicarboxylic acid monoamide obtained by formal condensation between the amino group of cis-4-aminocyclohexanecarboxylic acid and the cyclopentanecarboxylic acid group of 1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentanecarboxylic acid. A potent inhibitor of neutral endopeptidase (NEP,... AZD-4877 AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. Navarixin Navarixin has been investigated for the treatment of Asthma. Momelotinib Momelotinib has been used in trials studying the treatment of Polycythemia Vera, Primary Myelofibrosis, Post-Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis (PMF), among others. Danusertib Danusertib has been used in trials studying the treatment of Leukemia. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Mocetinostat Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. Entinostat Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic... Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Vistusertib Vistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma. Tasisulam Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others. Axelopran Axelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation. Tecovirimat An antiviral medication used to treat smallpox, monkeypox, and cowpox. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. N-6022 N6022 has been used in trials studying the treatment of Asthma and Cystic Fibrosis. Balicatib Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis. Defactinib Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Tacedinaline Tacedinaline has been used in trials studying the treatment of Lung Cancer, Multiple Myeloma, and Pancreatic Cancer. Bavisant Bavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity. Radotinib Radotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such... Idasanutlin Idasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia. LY-2456302 Ly2456302 has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. CI-1040 CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others. Lifibrol Lifibrol has been used in trials studying the basic science of Hyperlipoproteinemia and Hypercholesterolemia. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. BI-671800 Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial. MK-5108 MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors. MK-0686 MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic. AZD-9056 AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis. Etripamil Etripamil has been used in trials studying the treatment of Paroxysmal Supraventricular Tachycardia (PSVT). JNJ-41443532 JNJ-41443532 has been used in trials studying the basic science and treatment of Diabetes Mellitus, Type 2. Salirasib Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung. Relenopride Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation. CHF-6001 CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease. Tecarfarin Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism. Etalocib Etalocib has been used in trials studying the treatment of Pancreatic Cancer, Carcinoma, Non-Small-Cell Lung, and Unspecified Adult Solid Tumor, Protocol Specific. DA-6886 DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome. RO-4987655 RO4987655 has been used in trials studying the treatment of Neoplasms. Granotapide Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus. LY-2300559 Ly2300559 has been used in trials studying the prevention of Migraine Headache. Tucaresol Tucaresol has been used in trials studying the treatment of HIV Infections. Aminaphthone A medication that inhibits erythrocyte aggregation in capillaries, improving venous return for the treatment of capillary fragility. CEP-37440 CEP-37440 has been used in trials studying the treatment of Solid Tumors. SCYX-7158 SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African. 4SC-202 4SC-202 has been used in trials studying the treatment of Advanced Hematologic Malignancies. Iobenzamic acid Not Annotated Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. Rociverine An antispasmodic indicated in the treatment of urinary, gastrointestinal, and biliary tract spasms. Benorilate Not Annotated Nifuroxazide An antibiotic indicated in the treatment of susceptible gastrointestinal infections. Imidazole salicylate Not Annotated Iniparib Not Annotated Netarsudil A rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension. Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Thiosalicylic acid Not Annotated Brovanexine Not Annotated LGD-6972 LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). TAS-116 TAS-116 is under investigation in clinical trial NCT02965885 (A Study of TAS-116 in Patients With Solid Tumors). Galicaftor Galicaftor is under investigation in clinical trial NCT03540524 (A Study Looking at the Safety, Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without... Selonsertib Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). GTX-758 GTX-758 is under investigation in clinical trial NCT01420861 (GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer). Difamilast Difamilast is under investigation in clinical trial NCT01702181 (A Safety Study to Evaluate the Use and Effectiveness of a Topical Ointment to Treat Adults With Atopic Dermatitis). Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). ONO-8539 ONO-8539 is under investigation in clinical trial NCT01707901 (A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease). Acebilustat Acebilustat is under investigation in clinical trial NCT01748838 (Phase 1 Study Assessing the Safety and Tolerability of CTX-4430). AZD-9977 AZD-9977 is under investigation in clinical trial NCT03843060 (A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers). Giripladib Giripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee). Acumapimod Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers). Octyl triazone Not Annotated Ethyl salicylate A salicylate indicated in the treatment of sports related pain. TAK-715 TAK-715 is under investigation in clinical trial NCT00760864 (Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis). Cinaciguat Cinaciguat is under investigation in clinical trial NCT01067859 (A Phase Iib Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 ΜG/h, 10 ΜG/h) Given Intravenously to Patients... Acetyldinaline Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma). Fenpyroximate Fenpyroximate is under investigation in clinical trial NCT02533336 (The Effectiveness of Non-pyrethroid Insecticide-treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania). Trospium An antimuscarinic agent used to treat the symptoms of overactive bladder (OAB). Aminosalicylic acid An aminosalicylate drug used to induce remission in ulcerative colitis. Diatrizoate An injected contrast agent used in radiology. Aminohippuric acid A hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system. Nitisinone A hydroxyphenylpyruvate dioxygenase inhibitor used as an adjunct to dietary restrictions for the treatment of hereditary tyrosinemia type 1 (HT-1), which causes intolerance to tyrosine containing foods. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Cisapride A medication used to treat heartburn associated with GERD. Clidinium A synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Oxybuprocaine A local anesthetic used in ophthalmology. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Balsalazide An aminosalicylate used to treat ulcerative colitis. Procainamide A medication used to treat life threatening ventricular arrhythmias. Thalidomide A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Iodixanol A contrast agent used during coronary angiography, particularly in patients with renal dysfunction. Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Dimenoxadol Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United... Embutramide Not Available Metrizamide Metrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well... Deferasirox An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. p-Hydroxymercuribenzoic acid Not Available 3,4-Dihydroxycinnamic Acid Not Available 3-phenylpropionic acid Not Available Vanillic acid A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). O-Succinylbenzoate Not Available Flufenamic acid An analgesic drug used to relieve pain associated with rheumatoid diseases. Benzoylformic Acid Not Available Aminobenzoic acid A drug used to reduce the progression of penile deviation in Peyronie's Disease in adults. JE-2147 Not Available Compound 18 Not Available Phthalic Acid Not Available Isochorismic Acid Not Available P-Anisic Acid Not Available Mant-Adp Not Available KB-141 An anticholesteremic agent. Diphenylacetic acid Not Available 3-hydroxyanthranilic acid An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. p-Chlorobenzoic acid Not Available Benzoic acid An antimicrobial food additive. 3-Dehydroquinic Acid Not Available Phenylpyruvic acid Not Available Phloretic acid Not Available p-Coumaric acid Not Available Anthranilic acid Not Available 4-hydroxybenzoic acid Not Available Shikimate-3-Phosphate Not Available 3-Dehydroshikimate Not Available Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. Iodipamide A contrast agent used in cholangiography and cholecystography. Oxeladin Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity. Cyclandelate A vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis. Mepenzolate A postganglionic parasympathetic inhibitor that was previously approved for improving the healing of gastric ulcers, but has been discontinued. Darusentan For the treatment of congestive heart failure and hypertension. Ronacaleret Post-menopausal women with osteoporosis OMS-103HP Investigated for use/treatment in inflammatory disorders (unspecified), knee replacement, orthopedic surgery, and pain (acute or chronic). PX-478 Investigated for use/treatment in cancer/tumors (unspecified). Tanomastat Investigated for use/treatment in pancreatic cancer, lung cancer, ovarian cancer, and osteoarthritis. Ambrisentan A selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications. Declopramide Investigated for use/treatment in colorectal cancer and inflammatory bowel disease. Ticalopride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Ertiprotafib Investigated for use/treatment in diabetes mellitus type 2. Ragaglitazar Investigated for use/treatment in diabetes mellitus type 2. Tesaglitazar Investigated for use/treatment in diabetes mellitus type 2. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Aceclofenac Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Methenamine A urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Phenylbutyric acid An agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy. m-Hydroxyhippuric acid Not Available Isoferulic acid Not Available p-Nitrophenylacetic acid Not Available Acifluorfen Acifluorfen is a protoporphyrinogen oxidase inhibitor. Felbinac Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acid Not Available 4-Hydroxyphenylpyruvic acid Not Available Ferulic acid Not Available Homogentisic acid Not Available Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... 4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID Not Available Sinapic acid Sinapic acid is a matrix for matrix-assisted laser desorption technique for protein MW determination. It is also a constituent of propolis. 2-Hydroxybenzalpyruvate Not Available Methyl vanillate Not Available N-Caffeoyltyramine Not Available Glycerol phenylbutyrate A nitrogen-binding agent used to manage patients with urea cycle disorders who cannot be sufficiently managed amino acid supplementation and/or dietary restrictions. Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Iotroxic acid Iotroxic acid is a contrast medium molecule. Iopamidol A diagnostic imaging agent used for angiography throughout the cardiovascular system. Iodamide Iodamide is a contrast medium molecule that is no longer marketed in the United States. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Glafenine An anthranilic acid derivative with analgesic properties used for the relief of all types of pain. Glafenine is withdrawn from the American market. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Etofenamate An NSAID used to treat muscle and joint pain. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Benactyzine Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a... Tetracaine A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. Eugenol A phenol used for the temporary relief of toothaches. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Iothalamic acid A diagnostic contrast agent used in various medical imaging procedures, such as angiography, arthrography, and computed tomographic scans. Ioversol A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Ioxilan A diagnostic contrast agent used in various medical imaging procedures, such as angiography, urography, and computed tomographic scans. Iopromide An X-ray contrast agent used during various types of imaging tests such as angiography and contrast computed tomography (CT) imaging tests. Loxoprofen An NSAID used to treat pain and inflammation in musculoskeletal conditions. Dexibuprofen A pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. Dexketoprofen An NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Phenylacetic acid An agent used as an adjunct to treat acute hyperammonemia and associated encephalopathy in adult and pediatric patients with deficiencies in enzymes of the urea cycle. Morniflumate An NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems. Ioxaglic acid A tri-iodinated benzoate contrast agent used in various radiological procedures including angiography, phlebography, urography, computed tomography (CT), and hysterosalpingography. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Propoxycaine Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and... Metrizoic acid For use as a contrast medium . Acetrizoic acid Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.... Meglumine An amino sugar found in iodinated contrast media. Iotrolan Nonionic, isotonic contrast medium designed for intrathecal use. Octinoxate A sunscreen agent found in sunscreens that absorbs UV rays. Meradimate An ingredient used in sunscreens to absorb UV radiation. Amiloxate Indicated as an active sunscreen agent. Diethyltoluamide An insect repellant, also known as DEET. Ethyl ferulate Not Annotated Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Robenacoxib Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs. Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Iferanserin Iferanserin has been investigated for the treatment of Hemorrhoids. Iomeprol An iodine-based X-ray contrast agent. Arhalofenate Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia. Chlorogenic Acid Chlorogenic Acid has been used in trials studying the treatment of Advanced Cancer and Impaired Glucose Tolerance. CC-220 CC-220 has been used in trials studying the treatment of Systemic Lupus Erythematosus. Pelubiprofen Pelubiprofen has been investigated for the treatment of Chronic Back Pain. GDC-0810 ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer. Vidupiprant Vidupiprant has been used in trials studying the treatment and basic science of Asthma. Propiverine An antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency. Iobitridol An iodine-based contrast agent used with X-ray or CT imaging. PF-03635659 Pf03635659 has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease. Ioforminol Ioforminol has been used in trials studying the diagnostic of Cardio Renal Safety in High-risk Elderly Subjects Undergoing a Coronary CATH With or Without PCI. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Raclopride Raclopride has been used in trials studying Parkinson Disease. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. AZD-3043 AZD3043 has been used in trials studying the treatment and basic science of Safety, Sedation, Tolerability, and Pharmacokinetics. Naveglitazar Naveglitazar has been used in trials studying the treatment of Diabetes Mellitus, Non-Insulin-Dependent. Beloranib Beloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others. E-6005 E6005 has been used in trials studying the treatment of Atopic Dermatitis. Ataciguat Ataciguat has been investigated for the basic science of Aortic Valve Stenosis. XL-888 XL888 has been used in trials studying the treatment of Cancer and Melanoma. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Saroglitazar Saroglitazar has been investigated for the treatment of Fatty Liver. Lusutrombopag A medication used to treat thrombocytopenia in patients with chronic liver disease scheduled to have a procedure. Alclofenac Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Mandelic acid Mandelic acid is an approved aromatic, alpha hydroxy acid . Mandelic acid is used as an ingredient in cosmetics and drug products applied topically. Propanidid An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918) Hexobendine Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has... Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Picotamide A platelet aggregation inhibitor indicated in the treatment of myocardial infarction, thrombosis, cerebrovascular disorders, pulmonary emboli, and atherosclerosis. Dimethylphthalate Not Annotated Piperidolate Not Annotated Difemerine Not Annotated Ioxitalamic acid A contrast agent used for CT scans of the abdomen and pelvis. Poldine Not Annotated Veralipride Not Annotated Iodoxamic acid Radiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt. Bevonium Not Annotated Ethyl hydroxybenzoate Not Annotated Ioglicic acid Not Annotated Dibutylphthalate Not Annotated Pirprofen Not Annotated Butamirate A cough suppressant. Ioglycamic acid Not Annotated Iocarmic acid Not Annotated Tilidine A synthetic opioid indicated in the treatment of severe pain. Iopentol Iopentol is used as a contrast medium. Bismuth subgallate A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery. Butylparaben Not Annotated Benzylparaben Benzylparaben is used in allergenic testing. Propylparaben Propylparaben is used in allergenic testing. Isoeugenol Isoeugenol is approved by the FDA for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in... Methylparaben Methylparaben is used in allergenic testing. AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). CEP-9722 CEP-9722 is under investigation in clinical trial NCT01345357 (Study of CEP-9722 in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid Tumors or Mantle Cell Lymphoma). AZD-6482 AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482). AZD-9496 AZD-9496 is under investigation in clinical trial NCT02248090 (AZD9496 First Time in Patients Ascending Dose Study). Salvianolic acid A Salvianolic acid A is under investigation in clinical trial NCT03908242 (Phase I Study of Continuous Administration of Salvianolic Acid A Tablet). Iodohippuric acid Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults). Cinoxate Not Annotated Adiphenine Not Annotated Amfenac Not Annotated Levosulpiride indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting. GED-0507-34-Levo GED-0507-34-Levo is under investigation in clinical trial NCT02808390 (Efficacy and Safety Study of Ged-0507-34-levo for Treatment of UC). Vicagrel Vicagrel is under investigation in clinical trial NCT03599284 (The Efficacy, Safety and Pharmacokinetic of Antiplatelet Therapy for Vicagrel). Lavendustin b Not Annotated WZB-117 Not Annotated Methyl 2,5-dihydroxycinnamate Not Annotated Abscisic Acid Not Annotated Hippuric acid Not Annotated BMS-833923 Not Annotated Rosmarinic acid Not Annotated Ibuprofen piconol Not Annotated S-38093 Not Annotated - Drugs & Drug Targets