Neuroprotective Agents
- Name
- Neuroprotective Agents
- Accession Number
- DBCAT000653
- Description
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
- Drugs
Drug Drug Description 7-Nitroindazole Not Available Almitrine For the treatment of chronic obstructive pulmonary disease. AM336 Investigated for use/treatment in pain (acute or chronic). Aptiganel Aptiganel is a small molecule drug. Aptiganel has a monoisotopic molecular weight of 303.17 Da. Brimapitide Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). Butylphthalide Butylphthalide has been used in trials studying the prevention of Restenosis. Cerebrolysin A proteolytic protein indicated in the treatment of cerebrovascular disorders. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Clomethiazole Investigated for use/treatment in strokes. D-JNKI-1 Investigated for use/treatment in hearing loss. Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders. Dextrorphan Not Annotated Dizocilpine Dizocilpine is a small molecule drug. Dizocilpine has a monoisotopic molecular weight of 221.12 Da. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Edaravone A free radical scavenger used to delay the progression of ALS. Eliprodil Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders. Enadoline Not Annotated Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Fosfructose A phosphorylated form of fructose indicated in the treatment of hypophosphatemia. Gacyclidine Gacyclidine has been used in trials studying the treatment of Tinnitus. Huperzine A Investigated for use/treatment in alzheimer's disease. Isospaglumic acid Isospaglumic acid is a small molecule drug. Isospaglumic acid is under investigation in clinical trial NCT06800274 (Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Allergic Subjects With... Linopirdine Not Annotated Lubeluzole Lubeluzole is a small molecule drug. Lubeluzole has a monoisotopic molecular weight of 433.16 Da. Meclofenoxate Not Annotated Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases. Methylprednisolone hemisuccinate A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline Not Available Nefiracetam Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease. Nerinetide Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy). Nizofenone Not Annotated Omberacetam Omberacetam is a small molecule drug. The usage of the INN stem '-racetam' in the name indicates that Omberacetam is a piracetam type amide type nootrope agent. Omberacetam has a... Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Propentofylline Investigated for use/treatment in alzheimer's disease. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Rimcazole Rimcazole is a small molecule drug. Rimcazole has a monoisotopic molecular weight of 321.22 Da. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. S-Nitrosoglutathione Not Annotated Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. SGS-742 Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders. Siagoside Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a... Sipatrigine Sipatrigine is a small molecule drug. The usage of the INN stem '-trigine' in the name indicates that Sipatrigine is a sodium channel blocker, signal transduction modulator. Sipatrigine has a... Sodium dichloroacetate Not Annotated SP-8203 SP-8203 has been used in trials studying the treatment of Ischemic Stroke. Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Tenocyclidine Because of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors. Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Topiramate An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. Vasoactive intestinal peptide Not Annotated Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Z-Val-Ala-Asp fluoromethyl ketone Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the... Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. - Drugs & Drug Targets