- Neuroprotective Agents
- Accession Number
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Drug Drug Description Topiramate An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Tenocyclidine Because of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors. 7-Nitroindazole Not Available N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline Not Available Huperzine A Investigated for use/treatment in alzheimer's disease. SGS-742 Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders. D-JNKI-1 Investigated for use/treatment in hearing loss. Nalmefene An opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. Clomethiazole Investigated for use/treatment in strokes. Propentofylline Investigated for use/treatment in alzheimer's disease. Z-Val-Ala-Asp fluoromethyl ketone Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the... Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Epigallocatechin gallate Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Tempol Tempol has been used in trials studying the treatment of Anal Cancer. Butylphthalide Butylphthalide has been used in trials studying the prevention of Restenosis. Eliprodil Eliprodil has been used in trials studying the treatment of Parkinson Disease and Movement Disorders. Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Nefiracetam Nefiracetam has been used in trials studying the treatment of Alzheimer's Disease. Gacyclidine Gacyclidine has been used in trials studying the treatment of Tinnitus. Nizofenone Not Annotated Meclofenoxate Not Annotated Linopirdine Not Annotated Fosfructose A phosphorylated form of fructose indicated in the treatment of hypophosphatemia. Methylprednisolone hemisuccinate A water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders. Dextrorphan Not Annotated Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Almitrine For the treatment of chronic obstructive pulmonary disease. Brimapitide Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). Edaravone A free radical scavenger used to delay the progression of ALS. Rezafungin Rezafungin is under investigation in clinical trial NCT04368559 (Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation). Cerebrolysin A proteolytic protein indicated in the treatment of cerebrovascular disorders. Siagoside Siagoside (Sygen, AGF 2) has been investigated for the treatment of Parkinson Disease. It is a naturally occurring substance in the nerve cell’s membrane that is thought to play a...
- Drugs & Drug Targets