Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a... It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
- Mechanism
- Curator reviewed
clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system
- Primary indication
- Investigated for use/treatment in strokes.Curator reviewed
- Formula / weight
- C6H8ClNS · 161.65 g/mol (avg)
- Code names
- WY 1485
Resolves to
PCLITLDOTJTVDJ-UHFFFAOYSA-NSMILESCC1=C(CCCl)SC=N1What you can answer from here — as of August 30, 2026
Which drugs share a target with Clomethiazole, and which of those have an active Phase 3 trial?
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