Thioxanthenes

Name
Thioxanthenes
Accession Number
DBCAT001167
Description

Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.

Drugs
DrugDrug Description
FlupentixolA thioxanthene neuroleptic used to treat schizophrenia and depression.
ThiothixeneAn antipsychotic indicated for the management of schizophrenia.
ZuclopenthixolAn antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance.
ChlorprothixeneA thioxanthene antipsychotic.
ClopenthixolClopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.
Drugs & Drug Targets
DrugTargetType
FlupentixolAlpha-1A adrenergic receptortarget
FlupentixolD(2) dopamine receptortarget
FlupentixolD(1A) dopamine receptortarget
FlupentixolAromatic-L-amino-acid decarboxylaseenzyme
Flupentixol5-hydroxytryptamine receptor 2Atarget
FlupentixolATP-dependent translocase ABCB1transporter
FlupentixolMuscarinic acetylcholine receptor M1target
FlupentixolLiver carboxylesterase 1enzyme
FlupentixolD(3) dopamine receptortarget
FlupentixolD(4) dopamine receptortarget
Flupentixol5-hydroxytryptamine receptor 2Ctarget
ThiothixeneCytochrome P450 1A2enzyme
ThiothixeneCytochrome P450 2D6enzyme
ThiothixeneD(2) dopamine receptortarget
ThiothixeneD(1A) dopamine receptortarget
Thiothixene5-hydroxytryptamine receptor 2Atarget
ThiothixeneSolute carrier family 22 member 1transporter
ThiothixeneAlbumincarrier
ZuclopenthixolD(1A) dopamine receptortarget
ZuclopenthixolD(1B) dopamine receptortarget
ZuclopenthixolD(2) dopamine receptortarget
ZuclopenthixolCytochrome P450 2D6enzyme
ZuclopenthixolAlpha-1A adrenergic receptortarget
ZuclopenthixolAlpha-2A adrenergic receptortarget
Zuclopenthixol5-hydroxytryptamine receptor 2Atarget
ZuclopenthixolHistamine H1 receptortarget
ZuclopenthixolCytochrome P450 3A4enzyme
ChlorprothixeneD(1A) dopamine receptortarget
ChlorprothixeneD(2) dopamine receptortarget
ChlorprothixeneD(3) dopamine receptortarget
Chlorprothixene5-hydroxytryptamine receptor 2Atarget
ChlorprothixeneHistamine H1 receptortarget
ChlorprothixeneMuscarinic acetylcholine receptor M1target
ChlorprothixeneMuscarinic acetylcholine receptor M2target
ChlorprothixeneMuscarinic acetylcholine receptor M3target
ChlorprothixeneMuscarinic acetylcholine receptor M4target
ChlorprothixeneMuscarinic acetylcholine receptor M5target
ChlorprothixeneATP-dependent translocase ABCB1transporter
ChlorprothixeneSerotonin Receptorstarget
HycanthoneATP-dependent translocase ABCB1target
HycanthoneATP-dependent translocase ABCB1transporter
LucanthoneDNA topoisomerase 2-alphatarget
LucanthoneDNA repair nuclease/redox regulator APEX1target
LucanthoneDNAtarget
LucanthoneDNA topoisomerase 1target
LucanthoneDNA topoisomerase 2-betatarget