Clopenthixol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Clopenthixol
DrugBank Accession Number
DB13841
Background

Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 400.97
Monoisotopic: 400.1376123
Chemical Formula
C22H25ClN2OS
Synonyms
  • 4-(3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol
  • 4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol
  • Chlorpenthixol
  • Clopenthixol
  • Clopenthixolum
  • Clopentixol
  • Sordinol
External IDs
  • AY-62021
  • N-746

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Clopenthixol.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Clopenthixol.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Clopenthixol.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Clopenthixol.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Clopenthixol.
Food Interactions
Not Available

Products

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Categories

ATC Codes
N05AF02 — Clopenthixol
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
0A432D932A
CAS number
982-24-1
InChI Key
WFPIAZLQTJBIFN-UHFFFAOYSA-N
InChI
InChI=1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2
IUPAC Name
2-{4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]piperazin-1-yl}ethan-1-ol
SMILES
[H]C(CCN1CCN(CCO)CC1)=C1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2

References

General References
Not Available
KEGG Drug
D02613
ChemSpider
11945
BindingDB
81491
ChEBI
59115
ChEMBL
CHEMBL3989892
Wikipedia
Clopenthixol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Pill
Pill10 MG
Pill25 MG
Pill5 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0026 mg/mLALOGPS
logP4.46ALOGPS
logP4.22Chemaxon
logS-5.2ALOGPS
pKa (Strongest Acidic)15.59Chemaxon
pKa (Strongest Basic)8.03Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area26.71 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity127 m3·mol-1Chemaxon
Polarizability45.29 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0000900000-287e1befd2ec4535bd69
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-0009000000-b6d0192ff95c8dd70e50
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0159-1009000000-7fdc2e36119bb1125e9e
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-0090300000-767ede05c00fa50a789a
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-6019000000-b1ea6b9cb20d3e8ea22d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0596-0229100000-756d394a320a49bb509f
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 23, 2017 20:49 / Updated at February 21, 2021 18:54