Centrally Acting Antiobesity Products

Centrally Acting Antiobesity Products
Accession Number

Not Available

ATC Classification
DrugDrug Description
PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
MazindolA sympathomimetic used to treat obesity in combination with lifestyle modifications.
DiethylpropionAn appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction.
SibutramineA norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity.
DexfenfluramineFor the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
CathineUsed to decrease appetite.
LorcaserinA serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities.
EtilamfetamineEtilamfetamine is also known as N-ethylamphetamine and is in the Canadian Legislation - The Controlled Drugs and Substances Act, and is a Schedule 1 controlled drug. Like other amphetamines, this...
ClobenzorexNot Annotated
MefenorexNot Annotated
NaltrexoneA narcotic antagonist used in opioid overdose.
BupropionA norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
SetmelanotideSetmelanotide is indicated to treat obesity caused by genetic POMC, PCSK1, or LEPR deficiencies or Bardet-Biedl syndrome.
TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
Drugs & Drug Targets
PhentermineSodium-dependent noradrenaline transportertarget
PhentermineSodium-dependent dopamine transportertarget
PhentermineAmine oxidase [flavin-containing] Atarget
PhentermineAmine oxidase [flavin-containing] Btarget
PhentermineSodium-dependent serotonin transportertarget
PhenterminePro-neuropeptide Ytarget
PhentermineCytochrome P450 3A4enzyme
Fenfluramine5-hydroxytryptamine receptor 2Ctarget
Fenfluramine5-hydroxytryptamine receptor 2Btarget
FenfluramineCytochrome P450 2D6enzyme
FenfluramineSodium-dependent serotonin transportertarget
Fenfluramine5-hydroxytryptamine receptor 2Atarget
Fenfluramine5-hydroxytryptamine receptor 1Dtarget
FenfluramineSigma non-opioid intracellular receptor 1target
Fenfluramine5-hydroxytryptamine receptor 1Atarget
FenfluramineCytochrome P450 1A2enzyme
FenfluramineCytochrome P450 2B6enzyme
FenfluramineCytochrome P450 2C9enzyme
FenfluramineCytochrome P450 2C19enzyme
FenfluramineCytochrome P450 3A4enzyme
FenfluramineCytochrome P450 3A5enzyme
MazindolSodium-dependent noradrenaline transportertarget
MazindolSodium-dependent dopamine transportertarget
MazindolSodium-dependent serotonin transportertarget
MazindolSynaptic vesicular amine transportertarget
DiethylpropionSodium-dependent noradrenaline transportertarget
DiethylpropionSodium-dependent dopamine transportertarget
SibutramineSodium-dependent serotonin transportertarget
SibutramineSodium-dependent noradrenaline transportertarget
SibutramineCytochrome P450 3A4enzyme
SibutramineSodium-dependent dopamine transportertarget
DexfenfluramineSodium-dependent serotonin transportertarget
Dexfenfluramine5-hydroxytryptamine receptor 2Ctarget
DexfenfluramineCytochrome P450 2D6enzyme
DexfenfluramineCytochrome P450 1A2enzyme
DexfenfluramineCytochrome P450 2E1enzyme
Lorcaserin5-hydroxytryptamine receptor 2Ctarget
LorcaserinCytochrome P450 1A2enzyme
LorcaserinCytochrome P450 2A6enzyme
LorcaserinCytochrome P450 2B6enzyme
LorcaserinCytochrome P450 2C19enzyme
LorcaserinCytochrome P450 2D6enzyme
LorcaserinCytochrome P450 3A4enzyme
LorcaserinDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
LorcaserinCytochrome P450 1A1enzyme
NaltrexoneMu-type opioid receptortarget
NaltrexoneKappa-type opioid receptortarget
NaltrexoneDelta-type opioid receptortarget
NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
NaltrexoneSigma non-opioid intracellular receptor 1target
BupropionSodium-dependent dopamine transportertarget
BupropionSodium-dependent noradrenaline transportertarget
BupropionCytochrome P450 2B6enzyme
BupropionCytochrome P450 2D6enzyme
BupropionAlpha-1-acid glycoprotein 1carrier
BupropionNeuronal acetylcholine receptor subunit alpha-3target
BupropionCytochrome P450 2C9enzyme
BupropionCytochrome P450 2E1enzyme
BupropionSolute carrier family 22 member 2transporter
Bupropion5-hydroxytryptamine receptor 3Atarget
EphedrineAlpha-1A adrenergic receptortarget
EphedrineSodium-dependent noradrenaline transportertarget
EphedrineSerum albumincarrier
EphedrineBeta-1 adrenergic receptortarget
EphedrineBeta-2 adrenergic receptortarget
EphedrineSynaptic vesicular amine transportertransporter
SetmelanotideMelanocortin receptor 4target
TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
TopiramateVoltage-gated sodium channel alpha subunittarget
TopiramateCarbonic anhydrase 2target
TopiramateCarbonic anhydrase 4target
TopiramateKainate receptorstarget
TopiramateCytochrome P450 2C19enzyme
TopiramateCytochrome P450 3A4enzyme
TopiramateCarbonic anhydrase 1target
TopiramateCarbonic anhydrase 3target
TopiramateVoltage gated L-type calcium channeltarget
TopiramateVoltage-dependent R-type calcium channeltarget
TopiramateSerum albumincarrier
TopiramateP-glycoprotein 1transporter
Topiramate5'-AMP-activated protein kinasetransporter