Nucleoside Analog Antiviral

Name
Nucleoside Analog Antiviral
Accession Number
DBCAT003306
Description
Not Available
Drugs
DrugDrug Description
IdoxuridineA pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis.
TrifluridineA nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers.
RibavirinA guanosine nucleoside used to treat some forms of Hepatitis C.
GanciclovirA DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.
ValganciclovirAn antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS).
GS-441524An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections.
Drugs & Drug Targets
DrugTargetType
IdoxuridineThymidine kinasetarget
IdoxuridineDNAtarget
TrifluridineThymidylate synthasetarget
TrifluridineDNAtarget
TrifluridineThymidine kinase, cytosolicenzyme
TrifluridineThymidine phosphorylaseenzyme
TrifluridineSolute carrier family 22 member 6transporter
TrifluridineSodium/nucleoside cotransporter 1transporter
TrifluridineEquilibrative nucleoside transporter 1transporter
TrifluridineEquilibrative nucleoside transporter 2transporter
TrifluridineSerum albumincarrier
RibavirinRNA-directed RNA polymerase Ltarget
RibavirinRNA-directed RNA polymerase catalytic subunittarget
RibavirinInosine-5'-monophosphate dehydrogenase 1target
RibavirinGenome polyproteintarget
RibavirinInosine-5'-monophosphate dehydrogenase 2target
RibavirinAdenosine kinaseenzyme
RibavirinEquilibrative nucleoside transporter 1transporter
RibavirinSolute carrier family 28 member 3transporter
RibavirinCytosolic purine 5'-nucleotidaseenzyme
GanciclovirDNA polymerase catalytic subunittarget
GanciclovirThymidine kinasetarget
GanciclovirSolute carrier family 22 member 1transporter
GanciclovirSolute carrier family 22 member 6transporter
GanciclovirSolute carrier family 22 member 8transporter
GanciclovirSolute carrier family 22 member 7transporter
GanciclovirDNAtarget
GanciclovirMultidrug and toxin extrusion protein 1transporter
GanciclovirMultidrug and toxin extrusion protein 2transporter
ValganciclovirDNAtarget
ValganciclovirSolute carrier family 15 member 1transporter
ValganciclovirSolute carrier family 15 member 2transporter
ValganciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
GS-441524Replicase polyprotein 1abtarget
GS-441524RNA-directed RNA polymerase Ltarget