Miscellaneous Anxiolytics Sedatives and Hypnotics

Miscellaneous Anxiolytics Sedatives and Hypnotics
Accession Number

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DrugDrug Description
EszopicloneA sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep.
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
DroperidolA butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
BuspironeAn anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression.
HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
DexmedetomidineAn alpha-2 agonist used for sedation during various procedures.
ZaleplonA sedative used for short term treatment of insomnia in adults.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
ZopicloneA nonbenzodiazepine hypnotic used for the short-term management of insomnia.
Chloral hydrateA mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
ValerianA plant used in some non-prescription natural health products.
SuvorexantA orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
LemborexantA dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia.
Drugs & Drug Targets
EszopicloneCytochrome P450 3A4enzyme
EszopicloneGamma-aminobutyric acid receptor subunit alpha-1target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-2target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-3target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-5target
EszopicloneCytochrome P450 2C8enzyme
EszopicloneGABA(A) Receptortarget
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
DroperidolDopamine D2 receptortarget
DroperidolAlpha-1A adrenergic receptortarget
Buspirone5-hydroxytryptamine receptor 1Atarget
BuspironeDopamine D2 receptortarget
BuspironeCytochrome P450 3A4enzyme
BuspironeCytochrome P450 3A5enzyme
BuspironeCytochrome P450 3A7enzyme
BuspironeP-glycoprotein 1transporter
BuspironeCytochrome P450 2D6enzyme
BuspironeSerum albumincarrier
BuspironeAlpha-1-acid glycoprotein 1carrier
BuspironeDopamine D3 receptortarget
BuspironeDopamine D4 receptortarget
BuspironeAlpha-1 adrenergic receptorstarget
HydroxyzineHistamine H1 receptortarget
HydroxyzineCytochrome P450 2D6enzyme
HydroxyzineCytochrome P450 3A4enzyme
HydroxyzineCytochrome P450 3A5enzyme
HydroxyzinePotassium voltage-gated channel subfamily H member 2target
HydroxyzineP-glycoprotein 1transporter
HydroxyzineSerum albumincarrier
DexmedetomidineAlpha-2A adrenergic receptortarget
DexmedetomidineCytochrome P450 2E1enzyme
DexmedetomidineCytochrome P450 1A2enzyme
DexmedetomidineCytochrome P450 1A1enzyme
DexmedetomidineCytochrome P450 2D6enzyme
ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
ZaleplonCytochrome P450 3A4enzyme
ZaleplonAldehyde oxidaseenzyme
ZaleplonCytochrome P450 3A5enzyme
ZaleplonCytochrome P450 3A7enzyme
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
ZopicloneTranslocator proteintarget
ZopicloneCytochrome P450 2C8enzyme
ZopicloneCytochrome P450 2C9enzyme
ZopicloneCytochrome P450 3A4enzyme
ZopicloneProstaglandin G/H synthase 1enzyme
ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
SuvorexantOrexin receptor type 1target
SuvorexantOrexin receptor type 2target
SuvorexantCytochrome P450 3A4enzyme
SuvorexantP-glycoprotein 1transporter
LemborexantOrexin receptor type 1target
LemborexantOrexin receptor type 2target
LemborexantCytochrome P450 3A4enzyme
LemborexantCytochrome P450 3A5enzyme
LemborexantCytochrome P450 3A Subfamilyenzyme
LemborexantCytochrome P450 2B6enzyme
LemborexantP-glycoprotein 1transporter